ENPP1 inhibitor 32

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130320

CAS#: 2298391-60-1

Description: ENPP1 inhibitor 32 is an ENPP1 inhibitor with anti-tumor activity.

Chemical Structure

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ENPP1 inhibitor 32
CAS# 2298391-60-1
Instruction

Theoretical Analysis

MedKoo Cat#: 130320
Name: ENPP1 inhibitor 32
CAS#: 2298391-60-1
Chemical Formula: C16H22N3O4P
Exact Mass: 351.13
Molecular Weight: 351.340
Elemental Analysis: C, 54.70; H, 6.31; N, 11.96; O, 18.21; P, 8.82

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ENPP1 inhibitor 32

IUPAC/Chemical Name: (2-(1-(8-methoxyquinazolin-4-yl)piperidin-4-yl)ethyl)phosphonic acid

InChi Key: IXXUGBPAQOKGTM-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H22N3O4P/c1-23-14-4-2-3-13-15(14)17-11-18-16(13)19-8-5-12(6-9-19)7-10-24(20,21)22/h2-4,11-12H,5-10H2,1H3,(H2,20,21,22)

SMILES Code: COC1=CC=CC2=C(N3CCC(CCP(O)(O)=O)CC3)N=CN=C12

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 351.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Carozza JA, Brown JA, Böhnert V, Fernandez D, AlSaif Y, Mardjuki RE, Smith M, Li L. Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP. Cell Chem Biol. 2020 Nov 19;27(11):1347-1358.e5. doi: 10.1016/j.chembiol.2020.07.007. Epub 2020 Jul 28. PMID: 32726585; PMCID: PMC7680421.