CC-1088

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205831

CAS#: 467421-06-3

Description: CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6).


Price and Availability

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10mg
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100mg
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1g
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10g
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25mg
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200mg
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2g
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20g
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50mg
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500mg
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5g
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50g
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CC-1088, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 205831
Name: CC-1088
CAS#: 467421-06-3
Chemical Formula: C17H14N2O3
Exact Mass: 294.1004
Molecular Weight: 294.31
Elemental Analysis: C, 69.38; H, 4.79; N, 9.52; O, 16.31


Synonym: CC1088; CC 1088; CC-1088.

IUPAC/Chemical Name: 3-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanamide

InChi Key: ZJZWDDCSXLSDJG-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H14N2O3/c18-15(20)10-14(11-6-2-1-3-7-11)19-16(21)12-8-4-5-9-13(12)17(19)22/h1-9,14H,10H2,(H2,18,20)

SMILES Code: O=C(C1=CC=CC=C12)N(C(C3=CC=CC=C3)CC(N)=O)C2=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Dredge K. CC-1088 Celgene. Curr Opin Investig Drugs. 2005 May;6(5):513-7.
Review. PubMed PMID: 15912966.

2: Molostvov G, Morris A, Rose P, Basu S, Muller G. The effects of selective
cytokine inhibitory drugs (CC-10004 and CC-1088) on VEGF and IL-6 expression and
apoptosis in myeloma and endothelial cell co-cultures. Br J Haematol. 2004
Feb;124(3):366-75. PubMed PMID: 14717786.