CRTH2 antagonist K604

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130188

CAS#: N/A

Description: CRTH2 antagonist K604 is a CRTH2 antagonist (Ki=11 nM) with inhibitory effects. It has been hypothesized that CRTH2 plays an important role in the development/progression/outcome of allergic diseases, with K604 serving as a potential route for exploring the extent of CRTH2 involvement.

Chemical Structure

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CRTH2 antagonist K604
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 130188
Name: CRTH2 antagonist K604
CAS#: N/A
Chemical Formula: C27H26N2O2
Exact Mass: 410.20
Molecular Weight: 410.520
Elemental Analysis: C, 79.00; H, 6.38; N, 6.82; O, 7.79

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: CRTH2 antagonist K604

IUPAC/Chemical Name: N-((2R,4S)-1-benzoyl-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)-N-phenylcyclopropanecarboxamide

InChi Key: VGFZCFWVSYIXEK-CLOONOSVSA-N

InChi Code: InChI=1S/C27H26N2O2/c1-19-18-25(29(27(31)21-16-17-21)22-12-6-3-7-13-22)23-14-8-9-15-24(23)28(19)26(30)20-10-4-2-5-11-20/h2-15,19,21,25H,16-18H2,1H3/t19-,25+/m1/s1

SMILES Code: O=C(C1CC1)N([C@H]2C[C@@H](C)N(C(C3=CC=CC=C3)=O)C4=C2C=CC=C4)C5=CC=CC=C5

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 410.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Mimura H, Ikemura T, Kotera O, Sawada M, Tashiro S, Fuse E, Ueno K, Manabe H, Ohshima E, Karasawa A, Miyaji H. Inhibitory effect of the 4-aminotetrahydroquinoline derivatives, selective chemoattractant receptor-homologous molecule expressed on T helper 2 cell antagonists, on eosinophil migration induced by prostaglandin D2. J Pharmacol Exp Ther. 2005 Jul;314(1):244-51. doi: 10.1124/jpet.104.081539. Epub 2005 Mar 29. PMID: 15798001.