MC0704

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MedKoo CAT#: 122751

CAS#: N/A

Description: MC0704 is a STAT3 Pathway Inhibitors for Docetaxel-Resistant Triple-Negative Breast Cancer. MC0704 effectively impeded the metastatic potential of MDA-MB-231-DTR cells in vitro, and the combination of MC0704 and docetaxel exhibited potent antitumor activities in a xenograft mouse model.

Chemical Structure

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MC0704
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 122751
Name: MC0704
CAS#: N/A
Chemical Formula: C29H21BrN4O2
Exact Mass: 536.08
Molecular Weight: 537.420
Elemental Analysis: C, 64.81; H, 3.94; Br, 14.87; N, 10.43; O, 5.95

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MC0704; MC-0704; MC 0704

IUPAC/Chemical Name: N-(2-(1H-indol-3-yl)ethyl)-1-(4-bromobenzoyl)-9H-pyrido[3,4-b]indole-3-carboxamide

InChi Key: DLOFNWDJTXTZPF-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H21BrN4O2/c30-19-11-9-17(10-12-19)28(35)27-26-22(21-6-2-4-8-24(21)33-26)15-25(34-27)29(36)31-14-13-18-16-32-23-7-3-1-5-20(18)23/h1-12,15-16,32-33H,13-14H2,(H,31,36)

SMILES Code: O=C(C1=CC=C(Br)C=C1)C2=NC(C(NCCC3=CNC4=C3C=CC=C4)=O)=CC5=C2NC6=CC=CC=C65

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 537.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Byun WS, Lim H, Hong J, Bae ES, Lee SB, Kim Y, Lee J, Lee SK, Hong S. Design, Synthesis, and Biological Activity of Marinacarboline Analogues as STAT3 Pathway Inhibitors for Docetaxel-Resistant Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 14. doi: 10.1021/acs.jmedchem.2c01115. Epub ahead of print. PMID: 36786551.