CDD-1115

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MedKoo CAT#: 122678

CAS#: N/A

Description: CDD-1115 is a potent and BMPR2-selective kinase inhibitor. CDD-1115 Selectively Inhibits BMPR2 with Kiapp values for CDD-1115 (6.2 ± 1.3 nM). CDD-1115 exhibited superior selectivity and potency IC50 of 1.8 nM selectivity over BMPR2 among all other TGFβ family kinases. In this assay, CDD-1115 showed weak inhibition (>250 nM) of ALK1 and ALK2 (>100-fold over BMPR2) and poor inhibition (>1000 nM) of ALK3, ALK5, ALK6, and TGFBR2 (>555-fold over BMPR2) and was inactive in inhibiting ALK4, ACVR2A, and ACVR2B.

Chemical Structure

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CDD-1115
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 122678
Name: CDD-1115
CAS#: N/A
Chemical Formula: C32H30N6O3
Exact Mass: 546.24
Molecular Weight: 546.630
Elemental Analysis: C, 70.31; H, 5.53; N, 15.37; O, 8.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: CDD-1115; CDD1115; CDD 1115;

IUPAC/Chemical Name: N-(3-carbamoylbenzyl)-2-(isoquinolin-6-yl)-1-((1R,3R)-3-(methylcarbamoyl)cyclopentyl)-1H-benzo[d]imidazole-6-carboxamide

InChi Key: UOCCUBNXBUXTNS-ZEQKJWHPSA-N

InChi Code: InChI=1S/C32H30N6O3/c1-34-31(40)23-7-9-26(15-23)38-28-16-24(32(41)36-17-19-3-2-4-21(13-19)29(33)39)8-10-27(28)37-30(38)22-5-6-25-18-35-12-11-20(25)14-22/h2-6,8,10-14,16,18,23,26H,7,9,15,17H2,1H3,(H2,33,39)(H,34,40)(H,36,41)/t23-,26-/m1/s1

SMILES Code: NC(C1=CC(CNC(C2=CC=C3C(N([C@@H]4CC[C@@H](C(NC)=O)C4)C(C5=CC(C=CN=C6)=C6C=C5)=N3)=C2)=O)=CC=C1)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 546.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Modukuri RK, Monsivais D, Li F, Palaniappan M, Bohren KM, Tan Z, Ku AF, Wang Y, Madasu C, Li JY, Tang S, Miklossy G, Palmer SS, Young DW, Matzuk MM. Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening. J Med Chem. 2023 Jan 31. doi: 10.1021/acs.jmedchem.2c01886. Epub ahead of print. PMID: 36719862.