CEE321
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 122572

CAS#: 2098545-89-0

Description: CEE321 is a potent pan JAK inhibitor in enzyme and cellular assays (IC50 = 54 nM). CEE321 potently inhibited biomarkers relevant to atopic dermatitis.

Chemical Structure

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CEE321
CAS# 2098545-89-0
Instruction

Theoretical Analysis

MedKoo Cat#: 122572
Name: CEE321
CAS#: 2098545-89-0
Chemical Formula: C18H16ClN5O
Exact Mass: 353.10
Molecular Weight: 353.810
Elemental Analysis: C, 61.11; H, 4.56; Cl, 10.02; N, 19.79; O, 4.52

Price and Availability

Size Price Availability Quantity
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1350 2 Weeks
500mg USD 2850 2 Weeks
1g USD 3850 2 Weeks
2g USD 5950 2 Weeks
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Synonym: CEE321; CEE-321; CEE 321

IUPAC/Chemical Name: 4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide

InChi Key: OYWNKAAPXTYEBN-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H16ClN5O/c1-11-5-4-8-16(22-11)24-17-9-15(12(10-21-17)18(20)25)23-14-7-3-2-6-13(14)19/h2-10H,1H3,(H2,20,25)(H2,21,22,23,24)

SMILES Code: NC(C1=CN=C(NC2=NC(C)=CC=C2)C=C1NC3=CC=CC=C3Cl)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 353.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Reconstitution Calculator

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Thoma G, Duthaler RO, Waelchli R, Hauchard A, Bruno S, Strittmatter-Keller U, Orjuela Leon A, Viebrock S, Aichholz R, Beltz K, Grove K, Hoque S, Rudewicz PJ, Zerwes HG. Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis. J Med Chem. 2023 Jan 19. doi: 10.1021/acs.jmedchem.2c01977. Epub ahead of print. PMID: 36657024.