AZD3759
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206182

CAS#: 1626387-80-1

Description: AZD3759 is a n orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.


Price and Availability

Size
Price

25mg
USD 90
200mg
USD 450
2g
USD 1950
Size
Price

50mg
USD 150
500mg
USD 750
5g
USD 2950
Size
Price

100mg
USD 250
1g
USD 1250
10g
Ask price

AZD3759, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 5g may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206182
Name: AZD3759
CAS#: 1626387-80-1
Chemical Formula: C22H23ClFN5O3
Exact Mass: 459.14735
Molecular Weight: 459.91
Elemental Analysis: C, 57.46; H, 5.04; Cl, 7.71; F, 4.13; N, 15.23; O, 10.44


Synonym: AZD3759; AZD-3759; AZD 3759.

IUPAC/Chemical Name: (R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate

InChi Key: MXDSJQHFFDGFDK-CYBMUJFWSA-N

InChi Code: InChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H,25,26,27)/t13-/m1/s1

SMILES Code: O=C(N1[C@H](C)CN(C)CC1)OC2=CC3=C(NC4=CC=CC(Cl)=C4F)N=CN=C3C=C2OC


Technical Data

Appearance:
white to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Tan CS, Cho BC, Soo RA. Next-generation epidermal growth factor receptor
tyrosine kinase inhibitors in epidermal growth factor receptor -mutant non-small
cell lung cancer. Lung Cancer. 2016 Mar;93:59-68. doi:
10.1016/j.lungcan.2016.01.003. Epub 2016 Jan 8. Review. PubMed PMID: 26898616.

2: Zeng Q, Wang J, Cheng Z, Chen K, Johnström P, Varnäs K, Li DY, Yang ZF, Zhang
X. Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active,
Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine
Kinase Inhibitor. J Med Chem. 2015 Oct 22;58(20):8200-15. doi:
10.1021/acs.jmedchem.5b01073. Epub 2015 Oct 9. PubMed PMID: 26313252.

  (Last updated: 4/20/2016).