WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 200270
Description: Daporinad, also known as APO-866 and FK866, is a small molecule with potential antineoplastic and antiangiogenic activities. NMPRTase inhibitor APO866 binds to and inhibits nicotinamide phosphoribosyltransferase (NMPRTase), inhibiting the biosynthesis of nicotinamide adenine dinucleotide (NAD+) from niacinamide (vitamin B3), which may deplete energy reserves in metabolically active tumor cells and induce tumor cell apoptosis. In addition, this agent may inhibit tumor cell prioduction of vascular endothelial growth factor (VEGF), resulting in the inhibition of tumor angiogenesis.
MedKoo Cat#: 200270
Chemical Formula: C24H29N3O2
Exact Mass: 391.22598
Molecular Weight: 391.51
Elemental Analysis: C, 73.63; H, 7.47; N, 10.73; O, 8.17.
Related CAS #: 658084-64-1 201034-75-5
Synonym: APO866; APO-866; APO 866; FK 866; FK-866; FK866; Daporinad
IUPAC/Chemical Name: (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide
InChi Key: KPBNHDGDUADAGP-VAWYXSNFSA-N
InChi Code: InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
SMILES Code: O=C(NCCCCC1CCN(C(C2=CC=CC=C2)=O)CC1)/C=C/C3=CC=CN=C3