Lipid A6
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MedKoo CAT#: 556157

CAS#: N/A

Description: Lipid A6 is an ionizable and biodegradable lipid. Lipid A6 has similar structure as Dlin-MC3-DMA but with ester and alkyne bonds to improve its biodegradability and cell membrane fusion ability. Lipid A6 forms lipid-like nanoparticles together with cKK-E12 synergistically to facilitate robust mRNA delivery with improved tolerability. MC3 is the key delivery nanoparticle component of the first siRNA drug Onpattro.

Chemical Structure

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Lipid A6
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 556157
Name: Lipid A6
CAS#: N/A
Chemical Formula: C43H75NO6
Exact Mass: 701.56
Molecular Weight: 702.074
Elemental Analysis: C, 73.56; H, 10.77; N, 2.00; O, 13.67

Price and Availability

Size Price Availability Quantity
10mg USD 450 2 Weeks
25mg USD 850 2 Weeks
100mg USD 1950 2 Weeks
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Synonym: Lipid A6; LipidA6; Lipid-A6

IUPAC/Chemical Name: di(dec-3-yn-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate

InChi Key: KBXFPWUGHXHAKA-UHFFFAOYSA-N

InChi Code: InChI=1S/C43H75NO6/c1-5-7-9-11-13-15-23-29-38-48-41(45)34-27-21-17-19-25-32-40(50-43(47)36-31-37-44(3)4)33-26-20-18-22-28-35-42(46)49-39-30-24-16-14-12-10-8-6-2/h40H,5-14,17-22,25-39H2,1-4H3

SMILES Code: CCCCCCC#CCCOC(CCCCCCCC(OC(CCCN(C)C)=O)CCCCCCCC(OCCC#CCCCCCC)=O)=O

Appearance: Liquid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 702.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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