AMG-337
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 204320

CAS#: 1173699-31-4

Description: AMG 337 is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 337 selectively binds to c-Met, thereby disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
USD 2950
Size
Price

25mg
USD 250
200mg
USD 1250
2g
USD 4250
Size
Price

50mg
USD 450
500mg
USD 2150
5g
Ask price

AMG-337, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 204320
Name: AMG-337
CAS#: 1173699-31-4
Chemical Formula: C23H22FN7O3
Exact Mass: 463.1768
Molecular Weight: 463.4734
Elemental Analysis: C, 59.60; H, 4.78; F, 4.10; N, 21.16; O, 10.36


Synonym: AMG337; AMG-337; AMG 337.

IUPAC/Chemical Name: (R)-6-(1-(8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one

InChi Key: DWHXUGDWKAIASB-CQSZACIVSA-N

InChi Code: InChI=1S/C23H22FN7O3/c1-14(30-5-4-20-18(23(30)32)9-17(11-25-20)34-7-6-33-3)21-27-28-22-19(24)8-15(13-31(21)22)16-10-26-29(2)12-16/h4-5,8-14H,6-7H2,1-3H3/t14-/m1/s1

SMILES Code: O=C1C2=C(N=CC(OCCOC)=C2)C=CN1[C@@H](C3=NN=C4C(F)=CC(C5=CN(C)N=C5)=CN43)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

 
 
 
 


References

  1: Lee J, Tran P, Klempner SJ. Targeting the MET Pathway in Gastric and
Oesophageal Cancers: Refining the Optimal Approach. Clin Oncol (R Coll Radiol).
2016 Feb 12. pii: S0936-6555(16)00035-2. doi: 10.1016/j.clon.2016.01.009. [Epub
ahead of print] PubMed PMID: 26880063.

2: Boezio AA, Copeland KW, Rex K, K Albrecht B, Bauer D, Bellon SF, Boezio C,
Broome MA, Choquette D, Coxon A, Dussault I, Hirai S, Lewis R, Lin MJ, Lohman J,
Liu J, Peterson EA, Potashman M, Shimanovich R, Teffera Y, Whittington DA, Vaida
KR, Harmange JC. Discovery of
(R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-y
l)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and
Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo
Antitumor Activity. J Med Chem. 2016 Feb 11. [Epub ahead of print] PubMed PMID:
26812066.

3: Aprile G, Leone F, Giampieri R, Casagrande M, Marino D, Faloppi L, Cascinu S,
Fasola G, Scartozzi M. Tracking the 2015 Gastrointestinal Cancers Symposium:
bridging cancer biology to clinical gastrointestinal oncology. Onco Targets Ther.
2015 May 22;8:1149-56. doi: 10.2147/OTT.S82624. eCollection 2015. Review. PubMed
PMID: 26045669; PubMed Central PMCID: PMC4447178.