PK 9084

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208516

CAS#: 77472-99-2

Description: PK 9084 is a Phenylquinoline, that allosterically modulates [35S]t-butylbicyclophosphorothionate binding to a chloride ionophore in rat brain via a novel Ro5 4864 binding site

Chemical Structure

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PK 9084
CAS# 77472-99-2
Instruction

Theoretical Analysis

MedKoo Cat#: 208516
Name: PK 9084
CAS#: 77472-99-2
Chemical Formula: C22H24N2
Exact Mass: 316.19
Molecular Weight: 316.450
Elemental Analysis: C, 83.50; H, 7.64; N, 8.85

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym:

IUPAC/Chemical Name: Quinoline, 2-phenyl-4-(2-(3-piperidinyl)ethyl)-

InChi Key: BRSGIGKMAFNWJD-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H24N2/c1-2-8-18(9-3-1)22-15-19(13-12-17-7-6-14-23-16-17)20-10-4-5-11-21(20)24-22/h1-5,8-11,15,17,23H,6-7,12-14,16H2

SMILES Code: C1(C2=CC=CC=C2)=NC3=CC=CC=C3C(CCC4CNCCC4)=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 316.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: File SE. Sedative effects of PK 9084 and PK 8165, alone and in combination with chlordiazepoxide. Br J Pharmacol. 1983 May;79(1):219-23. doi: 10.1111/j.1476-5381.1983.tb10515.x. PMID: 6871544; PMCID: PMC2044829.


2: Gee KW. Phenylquinolines PK 8165 and PK 9084 allosterically modulate [35S]t-butylbicyclophosphorothionate binding to a chloride ionophore in rat brain via a novel Ro5 4864 binding site. J Pharmacol Exp Ther. 1987 Mar;240(3):747-53. PMID: 3031273.


3: Keane PE, Simiand J, Morre M. The quinolines PK 8165 and PK 9084 possess benzodiazepine-like activity in vitro but not in vivo. Neurosci Lett. 1984 Mar 9;45(1):89-93. doi: 10.1016/0304-3940(84)90334-3. PMID: 6145125.


4: File SE, Lister RG. Quinolines and anxiety: anxiogenic effects of CGS 8216 and partial anxiolytic profile of PK 9084. Pharmacol Biochem Behav. 1983 Feb;18(2):185-8. doi: 10.1016/0091-3057(83)90361-1. PMID: 6132404.


5: File SE, Pellow S. The effects of putative anxiolytic compounds (PK 8165, PK 9084 and tracazolate) on the rat corticosterone response. Physiol Behav. 1985 Oct;35(4):583-6. doi: 10.1016/0031-9384(85)90144-1. PMID: 2866553.


6: Gee KW, Brinton RE, Yamamura HI. PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam. Brain Res. 1983 Mar 28;264(1):168-72. doi: 10.1016/0006-8993(83)91138-1. PMID: 6303496.


7: File SE, Wilks L. Effects of acute and chronic treatment on the pro- and anti-convulsant actions of CL 218, 872, PK 8165 and PK 9084, putative ligands for the benzodiazepine receptor. J Pharm Pharmacol. 1985 Apr;37(4):252-6. doi: 10.1111/j.2042-7158.1985.tb05054.x. PMID: 2860223.


8: Le Fur G, Mizoule J, Burgevin MC, Ferris O, Heaulme M, Gauthier A, Guérémy C, Uzan A. Multiple benzodiazepine receptors: evidence of dissociation between anticonflict and anticonvulsant properties by PK 8165 and PK 9084 (two quinoline derivatives). Life Sci. 1981 Mar 30;28(13):1439-48. doi: 10.1016/0024-3205(81)90375-1. PMID: 6264247.


9: Broekkamp CL, Le Pichon M, Lloyd KG. The comparative effects of benzodiazepines, progabide and PK 9084 on acquisition of passive avoidance in mice. Psychopharmacology (Berl). 1984;83(1):122-5. doi: 10.1007/BF00427435. PMID: 6429696.


10: File SE, Simmonds MA. Interactions of two phenylquinolines with picrotoxin and benzodiazepines in vivo and in vitro. Eur J Pharmacol. 1984 Jan 27;97(3-4):295-300. doi: 10.1016/0014-2999(84)90463-1. PMID: 6705827.