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MedKoo CAT#: 100803
CAS#: 175591-09-0 (HCl)
Description: Tapentadol is a centrally acting opioid analgesic of the benzenoid class with a dual mode of action as an agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI). Its analgesic properties come into effect within thirty-two minutes of oral administration, and last for 4–6 hours. This agent may be effective in the management of pain, cancer-related and other.
MedKoo Cat#: 100803
Name: Tapentadol HCl
CAS#: 175591-09-0 (HCl)
Chemical Formula: C14H24ClNO
Molecular Weight: 257.802
Elemental Analysis: C, 65.23; H, 9.38; Cl, 13.75; N, 5.43; O, 6.21
Related CAS #: 175591-23-8 (free base) 175591-09-0 (HCl)
Synonym: CG5503; CG-5503; CG 5503; Tapentadol; brand names: Nucynta, Palexia and Tapal.
IUPAC/Chemical Name: 3-((2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl)phenol hydrochloride
InChi Key: ZELFLGGRLLOERW-YECZQDJWSA-N
InChi Code: InChI=1S/C14H23NO.ClH/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12;/h6-9,11,14,16H,5,10H2,1-4H3;1H/t11-,14+;/m0./s1
SMILES Code: OC1=CC=CC([C@H](CC)[C@@H](C)CN(C)C)=C1.[H]Cl
Tapentadol (trade name Nucynta, Palexia, In India - ZYNTAP) is a centrally acting analgesic with a dual mode of action as an agonist at the μ-opioid receptor and as a norepinephrine reuptake inhibitor. While its analgesic actions have been compared to tramadol and oxycodone, its general potency is somewhere between tramadol and morphine in effectiveness. Tapentadol is a new molecular entity that is structurally similar to Tramadol (Tramal). It has opioid and nonopioid acitivity in a single compound. In the US, Tapentadol is FDA approved for the treatment of moderate to severe acute pain. Due to the dual mechanism of action as an opioid agonist and norepinephrine reuptake inhibitor, there is potential for off label use in chronic pain. (source: http://en.wikipedia.org/wiki/Tapentadol).
Grunenthal (Achen, Germany) and Johnson & Johnson Pharmaceutical Research & Development (Raritan, NL) are currently developing tapentadol hydrochloride (controlled release) for cancer pain.
Grunenthal (Achen, Germany) and Johnson & Johnson Pharmaceutical Research & Development (Raritan, NL) are currently developing
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