LTURM 34
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 112158

CAS#: 1879887-96-3

Description: LTURM 34 is an inhibitor of DNA protein kinase and inhibits the growth of HOP-92, SNB-75, and UO-31 cancer cells.

Chemical Structure

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LTURM 34
CAS# 1879887-96-3
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 112158
Name: LTURM 34
CAS#: 1879887-96-3
Chemical Formula: C24H18N2O3S
Exact Mass: 414.10
Molecular Weight: 414.479
Elemental Analysis: C, 69.55; H, 4.38; N, 6.76; O, 11.58; S, 7.74

Price and Availability

Size Price Availability Quantity
5mg USD 295 2 Weeks
10mg USD 560 2 Weeks
25mg USD 950 2 Weeks
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Synonym: LTURM 34; LTURM34; LTURM-34

IUPAC/Chemical Name: 8-(dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-benzo[e][1,3]oxazin-4-one

InChi Key: SMMSWOMXOZLOPI-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H18N2O3S/c27-23-19-9-3-6-16(21(19)29-24(25-23)26-11-13-28-14-12-26)18-8-4-7-17-15-5-1-2-10-20(15)30-22(17)18/h1-10H,11-14H2

SMILES Code: O=C1N=C(OC2=C(C=CC=C21)C3=C4SC5=CC=CC=C5C4=CC=C3)N6CCOCC6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: LTURM34 is a specific DNA-PK inhibitor (IC50=34 nM).
In vitro activity: From this series, compound 20k (LTURM34) (dibenzo[b,d]thiophen-4-yl) (IC50 = 0.034 μM) was identified as a specific DNA-PK inhibitor, 170 fold more selective for DNA-PK activity compared to PI3K activity. Reference: Eur J Med Chem. 2016 Mar 3;110:326-39. https://pubmed.ncbi.nlm.nih.gov/26854431/
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 5.0 12.06
DMSO 2.0 4.83

Preparing Stock Solutions

The following data is based on the product molecular weight 414.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Morrison R, Al-Rawi JM, Jennings IG, Thompson PE, Angove MJ. Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur J Med Chem. 2016 Mar 3;110:326-39. doi: 10.1016/j.ejmech.2016.01.042. Epub 2016 Jan 27. PMID: 26854431.
In vitro protocol: 1. Morrison R, Al-Rawi JM, Jennings IG, Thompson PE, Angove MJ. Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur J Med Chem. 2016 Mar 3;110:326-39. doi: 10.1016/j.ejmech.2016.01.042. Epub 2016 Jan 27. PMID: 26854431.
In vivo protocol: TBD

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