Nemadipine A
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 112139

CAS#: 54280-71-6

Description: Nemadipine A is an L-type calcium channel blocker.

Chemical Structure

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Nemadipine A
CAS# 54280-71-6
Instruction

Theoretical Analysis

MedKoo Cat#: 112139
Name: Nemadipine A
CAS#: 54280-71-6
Chemical Formula: C19H18F5NO4
Exact Mass: 419.12
Molecular Weight: 419.350
Elemental Analysis: C, 54.42; H, 4.33; F, 22.65; N, 3.34; O, 15.26

Price and Availability

Size Price Availability Quantity
5mg USD 260 2 Weeks
10mg USD 520 2 Weeks
25mg USD 870 2 Weeks
50mg USD 1310 2 Weeks
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Synonym: Nemadipine A

IUPAC/Chemical Name: diethyl 2,6-dimethyl-4-(perfluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

InChi Key: QABNLWXKUCMDBP-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18F5NO4/c1-5-28-18(26)9-7(3)25-8(4)10(19(27)29-6-2)11(9)12-13(20)15(22)17(24)16(23)14(12)21/h11,25H,5-6H2,1-4H3

SMILES Code: FC1=C(C2C(C(OCC)=O)=C(C)NC(C)=C2C(OCC)=O)C(F)=C(F)C(F)=C1F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.0 47.69
Ethanol 15.0 35.77
Methanol 100.0 238.46

Preparing Stock Solutions

The following data is based on the product molecular weight 419.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Park SH, Park SJ, Kim JO, Shin JH, Kim ES, Jo YK, Kim JS, Park SJ, Jin DH, Hwang JJ, Lee SJ, Jeong SY, Lee C, Kim I, Cho DH. Down-Regulation of Survivin by Nemadipine-A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis. Biomol Ther (Seoul). 2013 Jan;21(1):29-34. doi: 10.4062/biomolther.2012.088. PMID: 24009855; PMCID: PMC3762295.


2: Li L, Zheng J, Stevens M, Oltean S. A repositioning screen using an FGFR2 splicing reporter reveals compounds that regulate epithelial-mesenchymal transitions and inhibit growth of prostate cancer xenografts. Mol Ther Methods Clin Dev. 2022 Mar 17;25:147-157. doi: 10.1016/j.omtm.2022.03.005. PMID: 35402635; PMCID: PMC8971352.


3: Joyce PI, Satija R, Chen M, Kuwabara PE. The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration. PLoS Genet. 2012;8(3):e1002602. doi: 10.1371/journal.pgen.1002602. Epub 2012 Mar 29. PMID: 22479198; PMCID: PMC3315469.