Aspochalasin M
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 112113

CAS#: 1173040-34-0

Description: Aspochalasin M inhibits the growth of HL-60 cells (IC50 = 20 µM).

Chemical Structure

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Aspochalasin M
CAS# 1173040-34-0
Instruction

Theoretical Analysis

MedKoo Cat#: 112113
Name: Aspochalasin M
CAS#: 1173040-34-0
Chemical Formula: C24H35NO4
Exact Mass: 401.26
Molecular Weight: 401.550
Elemental Analysis: C, 71.79; H, 8.79; N, 3.49; O, 15.94

Price and Availability

Size Price Availability Quantity
2.5mg USD 1140 2 Weeks
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Synonym: Aspochalasin M

IUPAC/Chemical Name: (3S,3aR,4S,6aS,12S,15aS,E)-12-hydroxy-3-isobutyl-4,5,8-trimethyl-3,3a,4,6a,9,10,13,14-octahydro-1H-cycloundeca[d]isoindole-1,11,15(2H,12H)-trione

InChi Key: GBCXTRJHTIEBIA-CEXVAXOJSA-N

InChi Code: InChI=1S/C24H35NO4/c1-13(2)10-18-22-16(5)15(4)12-17-11-14(3)6-7-19(26)20(27)8-9-21(28)24(17,22)23(29)25-18/h11-13,16-18,20,22,27H,6-10H2,1-5H3,(H,25,29)/b14-11+/t16-,17+,18+,20+,22+,24-/m1/s1

SMILES Code: C/C1=C\[C@@]2([C@]3([C@@]([H])([C@@H](C(C)=C2)C)[C@@H](NC3=O)CC(C)C)C(CC[C@@H](C(CC1)=O)O)=O)[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 401.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhu H, Chen C, Tong Q, Li XN, Yang J, Xue Y, Luo Z, Wang J, Yao G, Zhang Y. Epicochalasines A and B: Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes. Angew Chem Int Ed Engl. 2016 Mar 1;55(10):3486-90. doi: 10.1002/anie.201511315. Epub 2016 Feb 2. PMID: 26836964.


2: Ding G, Chen L, Chen A, Tian X, Chen X, Zhang H, Chen H, Liu XZ, Zhang Y, Zou ZM. Trichalasins C and D from the plant endophytic fungus Trichoderma gamsii. Fitoterapia. 2012 Apr;83(3):541-4. doi: 10.1016/j.fitote.2011.12.021. Epub 2012 Jan 8. PMID: 22245082.


3: Teshima R, Ikebuchi H, Sekita S, Natori S, Terao T. Effects of various cytochalasins on the IgE-mediated serotonin release from rat basophilic leukemia cells. Int Arch Allergy Appl Immunol. 1985;78(3):237-42. doi: 10.1159/000233892. PMID: 2414228.