Rhapontigenin
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MedKoo CAT#: 112094

CAS#: 500-65-2

Description: Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity.

Chemical Structure

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Rhapontigenin
CAS# 500-65-2
Instruction

Theoretical Analysis

MedKoo Cat#: 112094
Name: Rhapontigenin
CAS#: 500-65-2
Chemical Formula: C15H14O4
Exact Mass: 258.09
Molecular Weight: 258.270
Elemental Analysis: C, 69.76; H, 5.46; O, 24.78

Price and Availability

Size Price Availability Quantity
1mg USD 280 2 Weeks
5mg USD 760 2 Weeks
10mg USD 1230 2 Weeks
25mg USD 2170 2 Weeks
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Synonym: Rhapontigenin

IUPAC/Chemical Name: (Z)-5-(3-hydroxy-4-methoxystyryl)benzene-1,3-diol

InChi Key: PHMHDRYYFAYWEG-IHWYPQMZSA-N

InChi Code: InChI=1S/C15H14O4/c1-19-15-5-4-10(8-14(15)18)2-3-11-6-12(16)9-13(17)7-11/h2-9,16-18H,1H3/b3-2-

SMILES Code: COc1c(O)cc(/C=C\c2cc(O)cc(O)c2)cc1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 30.0 116.16
DMSO 30.0 116.16
Ethanol 30.0 116.16

Preparing Stock Solutions

The following data is based on the product molecular weight 258.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jung DB, Lee HJ, Jeong SJ, Lee HJ, Lee EO, Kim YC, Ahn KS, Chen CY, Kim SH. Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells. Biol Pharm Bull. 2011;34(6):850-5. doi: 10.1248/bpb.34.850. PMID: 21628883.


2: Roupe KA, Helms GL, Halls SC, Yáñez JA, Davies NM. Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies. J Pharm Pharm Sci. 2005 Aug 22;8(3):374-86. PMID: 16401387.


3: Kim JS, Kang CG, Kim SH, Lee EO. Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells. J Nat Prod. 2014 May 23;77(5):1135-9. doi: 10.1021/np401078g. Epub 2014 May 14. PMID: 24828286.