Maropitant
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 120201

CAS#: 147116-67-4

Description: Maropitant (trade name Cerenia in the US and other countries), used as maropitant citrate (USAN), is a neurokinin (NK1) receptor antagonist, which was developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by the FDA in 2007 for use in dogs, and more recently has also been approved for use in cats.


Price and Availability

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10mg
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100mg
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1g
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25mg
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200mg
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2g
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50mg
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500mg
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5g
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Maropitant is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 120201
Name: Maropitant
CAS#: 147116-67-4
Chemical Formula: C32H40N2O
Exact Mass: 468.31406
Molecular Weight: 468.6728
Elemental Analysis: C, 82.01; H, 8.60; N, 5.98; O, 3.41


Synonym: CJ-11,972; CJ 11,972; CJ11,972. Maropitant; brand name: Cerenia

IUPAC/Chemical Name: (1R,2S,3S,4R)-2-benzhydryl-N-(5-(tert-butyl)-2-methoxybenzyl)quinuclidin-3-amine

SMILES Code: COC1=CC=C(C(C)(C)C)C=C1CN[C@@H]2[C@H](C(C3=CC=CC=C3)C4=CC=CC=C4)[N@]5CC[C@]2([H])CC5


Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Johnson RA. Maropitant prevented vomiting but not gastroesophageal reflux in anesthetized dogs premedicated with acepromazine-hydromorphone. Vet Anaesth Analg. 2013 Dec 16. doi: 10.1111/vaa.12120. [Epub ahead of print] PubMed PMID: 24330310.

2: Niyom S, Boscan P, Twedt DC, Monnet E, Eickhoff JC. Effect of maropitant, a neurokinin-1 receptor antagonist, on the minimum alveolar concentration of sevoflurane during stimulation of the ovarian ligament in cats. Vet Anaesth Analg. 2013 Jul;40(4):425-31. doi: 10.1111/vaa.12017. Epub 2013 Feb 13. PubMed PMID: 23406526.

3: Lesman SP, Boucher JF, Grover GS, Cox SR, Bidgood TL. The pharmacokinetics of maropitant citrate dosed orally to dogs at 2 mg/kg and 8 mg/kg once daily for 14 days consecutive days. J Vet Pharmacol Ther. 2013 Oct;36(5):462-70. doi: 10.1111/jvp.12027. Epub 2012 Nov 20. PubMed PMID: 23167698.

4: Hay Kraus BL. Efficacy of maropitant in preventing vomiting in dogs premedicated with hydromorphone. Vet Anaesth Analg. 2013 Jan;40(1):28-34. doi: 10.1111/j.1467-2995.2012.00788.x. Epub 2012 Oct 20. PubMed PMID: 23082784.

5: Boscan P, Monnet E, Mama K, Twedt DC, Congdon J, Steffey EP. Effect of maropitant, a neurokinin 1 receptor antagonist, on anesthetic requirements during noxious visceral stimulation of the ovary in dogs. Am J Vet Res. 2011 Dec;72(12):1576-9. doi: 10.2460/ajvr.72.12.1576. PubMed PMID: 22126683.

6: Alvillar BM, Boscan P, Mama KR, Ferreira TH, Congdon J, Twedt DC. Effect of epidural and intravenous use of the neurokinin-1 (NK-1) receptor antagonist maropitant on the sevoflurane minimum alveolar concentration (MAC) in dogs. Vet Anaesth Analg. 2012 Mar;39(2):201-5. doi: 10.1111/j.1467-2995.2011.00670.x. Epub 2011 Nov 22. PubMed PMID: 22103569.

7: Mathis A, Lee K, Alibhai HI. The use of maropitant to prevent vomiting induced by epidural administration of preservative free morphine through an epidural catheter in a dog. Vet Anaesth Analg. 2011 Sep;38(5):516-7. doi: 10.1111/j.1467-2995.2011.00645.x. PubMed PMID: 21831059.

8: Williams-Fritze MJ, Carlson Scholz JA, Zeiss C, Deng Y, Wilson SR, Franklin R, Smith PC. Maropitant citrate for treatment of ulcerative dermatitis in mice with a C57BL/6 background. J Am Assoc Lab Anim Sci. 2011 Mar;50(2):221-6. PubMed PMID: 21439216; PubMed Central PMCID: PMC3061423.

9: Rau SE, Barber LG, Burgess KE. Efficacy of maropitant in the prevention of delayed vomiting associated with administration of doxorubicin to dogs. J Vet Intern Med. 2010 Nov-Dec;24(6):1452-7. doi: 10.1111/j.1939-1676.2010.0611.x. Epub 2010 Oct 12. PubMed PMID: 21039869.

10: Narishetty ST, Galvan B, Coscarelli E, Aleo M, Fleck T, Humphrey W, McCall RB. Effect of refrigeration of the antiemetic Cerenia (maropitant) on pain on injection. Vet Ther. 2009 Fall;10(3):93-102. PubMed PMID: 20037963.