Goserelin Acetate
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 100420

CAS#: 145781-92-6

Description: Goserelin is a synthetic decapeptide analog of luteinizing hormone-releasing hormone (LHRH) with antineoplastic activity. Goserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of goserelin inhibits the secretion of pituitary gonadotropin, thereby decreasing levels of testosterone (in males) and estradiol (in females). Administration of this agent in a depot formulation may result in the regression of sex hormone-sensitive tumors and a reduction in sex organ size and function.


Price and Availability

Size
Price

5mg
USD 70
50mg
USD 250
500mg
USD 1750
5g
USD 9850
Size
Price

10mg
USD 110
100mg
USD 450
1g
USD 2950
10g
USD 16850
Size
Price

25mg
USD 150
200mg
USD 850
2g
USD 4950
20g
Ask price

Goserelin Acetate, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 200mg may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 100420
Name: Goserelin Acetate
CAS#: 145781-92-6
Chemical Formula: C61H88N18O16
Exact Mass:
Molecular Weight: 1329.485
Elemental Analysis: C, 55.11; H, 6.67; N, 18.96; O, 19.25


Synonym: ICI118630; ICI-118630; ICI 118630; Goserelin Acetate; brand name: Zoladex.

IUPAC/Chemical Name: (S)-N-((6S,9S,12R,15S,18S,21S,24S)-21-((1H-indol-3-yl)methyl)-1-amino-12-(tert-butoxymethyl)-6-((S)-2-(2-carbamoylhydrazine-1-carbonyl)pyrrolidine-1-carbonyl)-15-(4-hydroxybenzyl)-18-(hydroxymethyl)-25-(1H-imidazol-4-yl)-1-imino-9-isobutyl-8,11,14,17,20,23-hexaoxo-2,7,10,13,16,19,22-heptaazapentacosan-24-yl)-5-oxopyrrolidine-2-carboxamide acetate

InChi Key: IKDXDQDKCZPQSZ-JHYYTBFNSA-N

InChi Code: InChI=1S/C59H84N18O14.C2H4O2/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38;1-2(3)4/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90);1H3,(H,3,4)/t38-,39-,40-,41-,42-,43-,44-,45+,46-;/m0./s1

SMILES Code: OC(C)=O.NC(NCCC[C@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC=N1)NC([C@@H]2CCC(N2)=O)=O)=O)CC3=CNC4=C3C=CC=C4)=O)CO)=O)CC5=CC=C(C=C5)O)=O)COC(C)(C)C)=O)CC(C)C)=O)C(N6CCC[C@H]6C(NNC(N)=O)=O)=O)=N


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO and in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

 Goserelin (free base)
Chemical Formula: C59H84N18O14
Exact Mass: 1268.6414
Molecular Weight: 1269.4330
Elemental Analysis: C, 55.82; H, 6.67; N, 19.86; O, 17.64


References

1: Roach M 3rd, Izaguirre A. Goserelin acetate in combination with radiotherapy for prostate cancer. Expert Opin Pharmacother. 2007 Feb;8(2):257-64. Review. PubMed PMID: 17257094.

2: Tsukagoshi S. [A new LH-RH agonist for treatment of prostate cancer, 3-month controlled-release formulation of goserelin acetate (Zoladex LA 10.8 mg depot)--outline of pre-clinical and clinical studies]. Gan To Kagaku Ryoho. 2002 Sep;29(9):1675-87. Review. Japanese. PubMed PMID: 12355959.

3: Koga H, Naito S. [Goserelin acetate depot, LH-RH agonist; its properties and therapeutic effects in prostate cancer]. Nihon Rinsho. 2000 Jul;58 Suppl:186-90. Review. Japanese. PubMed PMID: 11022711.

4: Goldspiel BR, Kohler DR. Goserelin acetate implant: a depot luteinizing hormone-releasing hormone analog for advanced prostate cancer. DICP. 1991 Jul-Aug;25(7-8):796-804. Review. PubMed PMID: 1835221.