3,3′-Dipropylthiadicarbocyanine (I)
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 112008

CAS#: 53213-94-8

Description: 3,3′-Dipropylthiadicarbocyanine (diSC3(5)) is a fluorescent dye that has been used to monitor cell membrane potential. It displays excitation/emission maxima of 622/670 nm, respectively, and, upon cell hyperpolarization, it enters cells, and exhibits a shift in emission maxima to 688 nm and a decrease in fluorescence intensity. When the cell membrane is depolarized, the fluorescence intensity of diSC3(5) increases as it exits the cells. However, diSC3(5) (3 µM) also induces membrane hyperpolarization, increases intracellular sodium levels, and decreases intracellular potassium levels in Ehrlich ascites tumor cells, as well as increases potassium membrane permeability by 64.6% in Ehrlich ascites tumor cells in the presence of the Na+/K+-ATPase inhibitor ouabain. It also reduces cellular ATP levels in the absence of glucose and induces acid production and inhibits oxygen consumption in the presence of glucose in Ehrlich ascites tumor cells when used at a concentration of 3 µM.

Chemical Structure

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3,3′-Dipropylthiadicarbocyanine (I)
CAS# 53213-94-8
Instruction

Theoretical Analysis

MedKoo Cat#: 112008
Name: 3,3′-Dipropylthiadicarbocyanine (I)
CAS#: 53213-94-8
Chemical Formula: C25H27IN2S2
Exact Mass: 0.00
Molecular Weight: 546.530
Elemental Analysis: C, 54.94; H, 4.98; I, 23.22; N, 5.13; S, 11.73

Price and Availability

Size Price Availability Quantity
25mg USD 250 2 Weeks
50mg USD 500 2 Weeks
100mg USD 770 2 Weeks
250mg USD 1200 2 Weeks
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Synonym: DiS-C3-(5); DiSC3(5); DiSC3 (5); 3,3′-Dipropylthiadicarbocyanine iodide; 3,3′Dipropylthiadicarbocyanine (I); 3,3′ Dipropylthiadicarbocyanine (I); 3,3′-Dipropylthiadicarbocyanine (I); 3,3′ Dipropylthiadicarbocyanine I; 3,3′-Dipropylthiadicarbocyanine I; 3,3′Dipropylthiadicarbocyanine I

IUPAC/Chemical Name: 3-propyl-2-((1E,3E,5E)-5-(3-propylbenzo[d]thiazol-2(3H)-ylidene)penta-1,3-dien-1-yl)benzo[d]thiazol-3-ium iodide

InChi Key: GDEURKKLNUGTDA-UHFFFAOYSA-M

InChi Code: InChI=1S/C25H27N2S2.HI/c1-3-18-26-20-12-8-10-14-22(20)28-24(26)16-6-5-7-17-25-27(19-4-2)21-13-9-11-15-23(21)29-25;/h5-17H,3-4,18-19H2,1-2H3;1H/q+1;/p-1

SMILES Code: CCCN(/C(S1)=C\C=C\C=C\C2=[N+](CCC)C(C=CC=C3)=C3S2)C4=C1C=CC=C4.[I-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.0 3.66

Preparing Stock Solutions

The following data is based on the product molecular weight 546.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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