SDZ-224015

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 466228

CAS#: unknown

Description: SDZ-224015 is HCV serine protease inhibitor.

Chemical Structure

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SDZ-224015
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 466228
Name: SDZ-224015
CAS#: unknown
Chemical Formula: C31H37Cl2N3O9
Exact Mass: 665.19
Molecular Weight: 666.549
Elemental Analysis: C, 55.86; H, 5.60; Cl, 10.64; N, 6.30; O, 21.60

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SDZ-224015; SDZ224015; SDZ 224015;

IUPAC/Chemical Name: ethyl (5S,6R,12S)-12-(2-((2,6-dichlorobenzoyl)oxy)acetyl)-6-isopropyl-5-methyl-3,7,10-trioxo-1-phenyl-2-oxa-4,8,11-triazatetradecan-14-oate

InChi Key: NTWVFYCDXRVJCY-HLULCQHTSA-N

InChi Code: InChI=1S/C31H37Cl2N3O9/c1-5-43-26(39)14-23(24(37)17-44-30(41)28-21(32)12-9-13-22(28)33)36-25(38)15-34-29(40)27(18(2)3)19(4)35-31(42)45-16-20-10-7-6-8-11-20/h6-13,18-19,23,27H,5,14-17H2,1-4H3,(H,34,40)(H,35,42)(H,36,38)/t19-,23-,27+/m0/s1

SMILES Code: O=C([C@@H](NC(CNC([C@@H]([C@H](C)NC(OCC1=CC=CC=C1)=O)C(C)C)=O)=O)CC(OCC)=O)COC(C2=C(C=CC=C2Cl)Cl)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 666.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Redhead MA, Owen CD, Brewitz L, Collette AH, Lukacik P, Strain-Damerell C, Robinson SW, Collins PM, Schäfer P, Swindells M, Radoux CJ, Hopkins IN, Fearon D, Douangamath A, von Delft F, Malla TR, Vangeel L, Vercruysse T, Thibaut J, Leyssen P, Nguyen TT, Hull M, Tumber A, Hallett DJ, Schofield CJ, Stuart DI, Hopkins AL, Walsh MA. Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19. Sci Rep. 2021 Jun 24;11(1):13208. doi: 10.1038/s41598-021-92416-4. Erratum in: Sci Rep. 2021 Sep 28;11(1):19633. PMID: 34168183; PMCID: PMC8225628.

2: Elford PR, Heng R, Révész L, MacKenzie AR. Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224-015, an inhibitor of the interleukin-1 beta converting enzyme. Br J Pharmacol. 1995 Jun;115(4):601-6. doi: 10.1111/j.1476-5381.1995.tb14974.x. PMID: 7582478; PMCID: PMC1908483.