HS-731

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 466162

CAS#: 547767-45-3

Description: HS-731 is a μ-Opioid Receptor Agonist.

Chemical Structure

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HS-731
CAS# 547767-45-3
Instruction

Theoretical Analysis

MedKoo Cat#: 466162
Name: HS-731
CAS#: 547767-45-3
Chemical Formula: C20H26N2O5
Exact Mass: 374.18
Molecular Weight: 374.437
Elemental Analysis: C, 64.15; H, 7.00; N, 7.48; O, 21.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: HS-731; HS731; HS 731;

IUPAC/Chemical Name: ((4R,4aS,7R,7aR,12bS)-9-hydroxy-4a-methoxy-3-methyl-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl)glycine

InChi Key: YHKUQEWICWSOTO-SWJKATBISA-N

InChi Code: InChI=1S/C20H26N2O5/c1-22-8-7-19-16-11-3-4-13(23)17(16)27-18(19)12(21-10-15(24)25)5-6-20(19,26-2)14(22)9-11/h3-4,12,14,18,21,23H,5-10H2,1-2H3,(H,24,25)/t12-,14-,18+,19+,20-/m1/s1

SMILES Code: OC1=CC=C2C3=C1O[C@@H]([C@H](NCC(O)=O)CC4)[C@@]3(CCN5C)[C@]4(OC)[C@H]5C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 374.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Puls K, Schmidhammer H, Wolber G, Spetea M. Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors. Molecules. 2022 Jan 28;27(3):919. doi: 10.3390/molecules27030919. PMID: 35164182; PMCID: PMC8840597.

2: Baillie LD, Schmidhammer H, Mulligan SJ. Peripheral μ-opioid receptor mediated inhibition of calcium signaling and action potential-evoked calcium fluorescent transients in primary afferent CGRP nociceptive terminals. Neuropharmacology. 2015 Jun;93:267-73. doi: 10.1016/j.neuropharm.2015.02.011. Epub 2015 Feb 24. PMID: 25721395.

3: Al-Khrasani M, Spetea M, Friedmann T, Riba P, Király K, Schmidhammer H, Furst S. DAMGO and 6beta-glycine substituted 14-O-methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens. Brain Res Bull. 2007 Oct 19;74(5):369-75. doi: 10.1016/j.brainresbull.2007.07.008. Epub 2007 Jul 30. PMID: 17845912.

4: Morokata T, Suzuki K, Masunaga Y, Taguchi K, Morihira K, Sato I, Fujii M, Takizawa S, Torii Y, Yamamoto N, Kaneko M, Yamada T, Takahashi K, Shimizu Y. A novel, selective, and orally available antagonist for CC chemokine receptor 3. J Pharmacol Exp Ther. 2006 Apr;317(1):244-50. doi: 10.1124/jpet.105.097048. Epub 2005 Dec 9. PMID: 16339911.

5: Bileviciute-Ljungar I, Spetea M, Guo Y, Schütz J, Windisch P, Schmidhammer H. Peripherally mediated antinociception of the mu-opioid receptor agonist 2-[(4,5alpha-epoxy-3-hydroxy-14beta-methoxy-17-methylmorphinan-6beta- yl)amino]acetic acid (HS-731) after subcutaneous and oral administration in rats with carrageenan-induced hindpaw inflammation. J Pharmacol Exp Ther. 2006 Apr;317(1):220-7. doi: 10.1124/jpet.105.096032. Epub 2005 Dec 8. PMID: 16339394.