AZD-3463
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206039

CAS#: 1356962-20-3

Description: AZD-3463 is a potent ALK/IGF1R inhibitor with potential anticancer activity. AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis. AZD3463 effectively suppressed the proliferation of NB cell lines with wild type ALK (WT) as well as ALK activating mutations (F1174L and D1091N) by blocking the ALK-mediated PI3K/AKT/mTOR pathway and ultimately induced apoptosis and autophagy. In addition, AZD3463 enhanced the cytotoxic effects of doxorubicin on NB cells. AZD3463 also exhibited significant therapeutic efficacy on the growth of the NB tumors with WT and F1174L activating mutation ALK in orthotopic xenograft mouse models.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
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Size
Price

25mg
USD 350
200mg
USD 950
2g
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Size
Price

50mg
USD 450
500mg
USD 1650
5g
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AZD3463, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 500mg may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206039
Name: AZD-3463
CAS#: 1356962-20-3
Chemical Formula: C24H25ClN6O
Exact Mass: 448.17784
Molecular Weight: 448.95
Elemental Analysis: C, 64.21; H, 5.61; Cl, 7.90; N, 18.72; O, 3.56


Synonym: AZD3463; AZD 3463; AZD-3463.

IUPAC/Chemical Name: N-(4-(4-aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine.

InChi Key: GCYIGMXOIWJGBU-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H25ClN6O/c1-32-22-12-16(31-10-8-15(26)9-11-31)6-7-21(22)29-24-28-14-19(25)23(30-24)18-13-27-20-5-3-2-4-17(18)20/h2-7,12-15,27H,8-11,26H2,1H3,(H,28,29,30)

SMILES Code: ClC1=CN=C(NC2=CC=C(N3CCC(N)CC3)C=C2OC)N=C1C4=CNC5=C4C=CC=C5


Technical Data

Appearance:
Light green to green solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

 1: Wang Y, Wang L, Guan S, Cao W, Wang H, Chen Z, Zhao Y, Yu Y, Zhang H, Pang JC,
Huang SL, Akiyama Y, Yang Y, Sun W, Xu X, Shi Y, Zhang H, Kim ES, Muscal JA, Lu
F, Yang J. Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by
overcoming crizotinib resistance and inducing apoptosis. Sci Rep. 2016 Jan
20;6:19423. doi: 10.1038/srep19423. PubMed PMID: 26786851; PubMed Central PMCID:
PMC4726162.

2: Sampson VB, Vetter NS, Kamara DF, Collier AB, Gresh RC, Kolb EA. Vorinostat
Enhances Cytotoxicity of SN-38 and Temozolomide in Ewing Sarcoma Cells and
Activates STAT3/AKT/MAPK Pathways. PLoS One. 2015 Nov 16;10(11):e0142704. doi:
10.1371/journal.pone.0142704. PubMed PMID: 26571493; PubMed Central PMCID:
PMC4646493.