LY2584702 tosylate salt
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MedKoo CAT#: 205522

CAS#: 1082949-68-5 (tosylate)

Description: LY-2584702, also known as LYS6K2, is an orally available inhibitor of p70S6K signaling, with potential antineoplastic activity. LY2584702 inhibits ribosomal protein S6 Kinase (p70S6K), and prevents phosphorylation of the S6 subunit of ribosomes, thereby inhibiting normal ribosomal function within tumor cells leading to a decrease in protein synthesis and in cellular proliferation. P70S6K, a serine/threonine kinase, acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway, is often upregulated in a variety of cancer cells, and is involved in the regulation of cell growth, proliferation, motility, and survival.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 650
1g
USD 2650
Size
Price

25mg
USD 250
200mg
USD 850
2g
USD 3850
Size
Price

50mg
USD 450
500mg
USD 1450
5g
USD 4750

LY2584702 tosylate, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 1 g may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 205522
Name: LY2584702 tosylate salt
CAS#: 1082949-68-5 (tosylate)
Chemical Formula: C28H27F4N7O3S
Exact Mass: 445.1638
Molecular Weight: 617.6236
Elemental Analysis: C, 54.45; H, 4.41; F, 12.30; N, 15.88; O, 7.77; S, 5.19


Related CAS #: 1082949-68-5 (tosylate)   1082949-67-4 (free base)    

Synonym: LY2584702; LY 2584702; LY-2584702; LYS6K2.

IUPAC/Chemical Name: 4-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine 4-methylbenzenesulfonate

InChi Key: HDYUXDNMHBQKAU-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H19F4N7.C7H8O3S/c1-31-10-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(31)12-4-6-32(7-5-12)20-14-9-28-30-18(14)26-11-27-20;1-6-2-4-7(5-3-6)11(8,9)10/h2-3,8-12H,4-7H2,1H3,(H,26,27,28,30);2-5H,1H3,(H,8,9,10)

SMILES Code: CN1C=C(C2=CC=C(F)C(C(F)(F)F)=C2)N=C1C3CCN(C4=C5C(NN=C5)=NC=N4)CC3.OS(=O)(C6=CC=C(C)C=C6)=O


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

 


References

1: Hollebecque A, Houédé N, Cohen EE, Massard C, Italiano A, Westwood P,
Bumgardner W, Miller J, Brail LH, Benhadji KA, Soria JC. A phase Ib trial of
LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or
everolimus in patients with solid tumours. Eur J Cancer. 2014 Mar;50(5):876-84.
doi: 10.1016/j.ejca.2013.12.006. Epub 2014 Jan 20. PubMed PMID: 24456794.

2: Tolcher A, Goldman J, Patnaik A, Papadopoulos KP, Westwood P, Kelly CS,
Bumgardner W, Sams L, Geeganage S, Wang T, Capen AR, Huang J, Joseph S, Miller J,
Benhadji KA, Brail LH, Rosen LS. A phase I trial of LY2584702 tosylate, a p70 S6
kinase inhibitor, in patients with advanced solid tumours. Eur J Cancer. 2014
Mar;50(5):867-75. doi: 10.1016/j.ejca.2013.11.039. Epub 2014 Jan 15. PubMed PMID:
24440085.