Tepotinib
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 201145

CAS#: 1100598-32-0

Description: Tepotinib, also known as EMD 1214063 and MSC2156119, is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor EMD 1214063 selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
USD 2950
Size
Price

25mg
USD 250
200mg
USD 1250
2g
Ask price
Size
Price

50mg
USD 450
500mg
USD 2050
5g
Ask price

Tepotinib ( EMD-1214063 ), purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 201145
Name: Tepotinib
CAS#: 1100598-32-0
Chemical Formula: C29H28N6O2
Exact Mass: 492.22737
Molecular Weight: 492.57
Elemental Analysis: C, 70.71; H, 5.73; N, 17.06; O, 6.50


Synonym: EMD1214063 EMD1214063 EMD 1214063; MSC2156119; MSC2156119; MSC2156119; Tepotinib.

IUPAC/Chemical Name: 3-(1-(3-(5-((1-methylpiperidin-4-yl)methoxy)pyrimidin-2-yl)benzyl)-1,6-dihydro-6-oxopyridazin-3-yl)benzonitrile

InChi Key: AHYMHWXQRWRBKT-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3

SMILES Code: N#CC1=CC=CC(C(C=C2)=NN(CC3=CC=CC(C4=NC=C(OCC5CCN(C)CC5)C=N4)=C3)C2=O)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

 
 


References

1: Kaplan D, Grinshtein N, Rioseco C, Luchman A, Datti A, Aman A, Uehling D, Prakesch M, Wrana J, Cairncross G, Shen Y, Jones S, Marra M, Senger D, Robbins S, Al-Awar R, Moran M, Weiss S. Combined drug screening and phosphoproteomics identifies candidate brain tumor therapeutics and novel targets in primary human brain tumor-initiating cells. Neuro Oncol. 2014 Jul;16 Suppl 3:iii20. doi: 10.1093/neuonc/nou206.72. PubMed PMID: 25165242.

2: Bladt F, Faden B, Friese-Hamim M, Knuehl C, Wilm C, Fittschen C, Grädler U, Meyring M, Dorsch D, Jaehrling F, Pehl U, Stieber F, Schadt O, Blaukat A. EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors. Clin Cancer Res. 2013 Jun 1;19(11):2941-51. doi: 10.1158/1078-0432.CCR-12-3247. Epub 2013 Apr 3. PubMed PMID: 23553846.

3: Walker K, Padhiar M. AACR-NCI-EORTC--21st International Symposium. Molecular targets and cancer therapeutics--Part 2. IDrugs. 2010 Jan;13(1):10-2. PubMed PMID: 20024839.