DS96432529
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MedKoo CAT#: 465728

CAS#: unknown

Description: DS96432529 is a potent and orally active bone anabolic agent. DS96432529 exhibited the best PK profile and high in vitro activity, showed the highest in vivo efficacy in this series. Moreover, significant synergistic effects were observed following co-administration of DS96432529 and alendronate or parathyroid hormone. The mechanism of action is most likely mediated through CDK8 inhibition.

Chemical Structure

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DS96432529
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 465728
Name: DS96432529
CAS#: unknown
Chemical Formula: C18H26N4O3S
Exact Mass: 378.17
Molecular Weight: 378.491
Elemental Analysis: C, 57.12; H, 6.92; N, 14.80; O, 12.68; S, 8.47

Price and Availability

Size Price Availability Quantity
5mg USD 750 2 Weeks
10mg USD 1250 2 Weeks
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Synonym: DS96432529; DS 96432529; DS-96432529;

IUPAC/Chemical Name: (S)-3-amino-4-(3-((2-ethoxyethoxy)methyl)piperidin-1-yl)thieno[2,3-b]pyridine-2-carboxamide

InChi Key: GOAKYBVMJUXOFY-LBPRGKRZSA-N

InChi Code: InChI=1S/C18H26N4O3S/c1-2-24-8-9-25-11-12-4-3-7-22(10-12)13-5-6-21-18-14(13)15(19)16(26-18)17(20)23/h5-6,12H,2-4,7-11,19H2,1H3,(H2,20,23)/t12-/m0/s1

SMILES Code: O=C(C1=C(N)C2=C(N3C[C@@H](COCCOCC)CCC3)C=CN=C2S1)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 378.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Saito K, Shinozuka T, Nakao A, Kunikata T, Nakai D, Nagai Y, Naito S. Discovery of 3-amino-4-{(3S)-3-[(2-ethoxyethoxy)methyl]piperidin-1-yl}thieno[2,3 -b]pyridine-2-carboxamide (DS96432529): A potent and orally active bone anabolic agent. Bioorg Med Chem Lett. 2021 Dec 15;54:128440. doi: 10.1016/j.bmcl.2021.128440. Epub 2021 Nov 3. PMID: 34742889.