TH-237A
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 510299

CAS#: 935467-97-3

Description: TH-237A is a novel neuroprotective agent, which possess protective properties against β-amyloid (Aβ)-induced neurodegeneration associated with Alzheimer's disease. Exposure of neuronal cultures to Aβ peptide in the presence of 5 nM TH-237A resulted in a 50% increase in survival. Neuronal cultures treated with other toxic stimuli such as staurosporine, thapsigargin, paraquat and H2O2 showed significantly enhanced survival in the presence of TH-237A . Microtubule binding and tubulin assembly studies revealed differences compared to paclitaxel, but confirmed the interaction of TH-237A with microtubules.


Price and Availability

Size
Price

50mg
USD 550
500mg
USD 1950
Size
Price

100mg
USD 950
1g
USD 2950
Size
Price

200mg
USD 1250
5g
Ask price

TH-237A, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 510299
Name: TH-237A
CAS#: 935467-97-3
Chemical Formula: C18H17F2NO3
Exact Mass: 333.11765
Molecular Weight: 333.33
Elemental Analysis: C, 64.86; H, 5.14; F, 11.40; N, 4.20; O, 14.40


Synonym: TH237A; TH 237A; TH237A. mesoGS 164.

IUPAC/Chemical Name: ((3R,5S,7as)-3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol.

SMILES Code: OC[C@@]12N([C@H](C3=CC=C(F)C=C3)OC2)[C@@H](C4=CC=C(F)C=C4)OC1


Technical Data

Appearance:
white to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
  
 
 


References

1: Desino KE, Ansar S, Georg GI, Himes RH, Michaelis ML, Powell DR, Reiff EA, Telikepalli H, Audus KL. (3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a novel neuroprotective agent. J Med Chem. 2009 Dec 10;52(23):7537-43. doi: 10.1021/jm900254k. PubMed PMID: 19728715; PubMed Central PMCID: PMC2788673.