WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510299
Description: TH-237A is a novel neuroprotective agent, which possess protective properties against β-amyloid (Aβ)-induced neurodegeneration associated with Alzheimer's disease. Exposure of neuronal cultures to Aβ peptide in the presence of 5 nM TH-237A resulted in a 50% increase in survival. Neuronal cultures treated with other toxic stimuli such as staurosporine, thapsigargin, paraquat and H2O2 showed significantly enhanced survival in the presence of TH-237A . Microtubule binding and tubulin assembly studies revealed differences compared to paclitaxel, but confirmed the interaction of TH-237A with microtubules.
MedKoo Cat#: 510299
Chemical Formula: C18H17F2NO3
Exact Mass: 333.11765
Molecular Weight: 333.33
Elemental Analysis: C, 64.86; H, 5.14; F, 11.40; N, 4.20; O, 14.40
Synonym: TH237A; TH 237A; TH237A. mesoGS 164.
IUPAC/Chemical Name: ((3R,5S,7as)-3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol.
SMILES Code: OC[C@@]12N([C@H](C3=CC=C(F)C=C3)OC2)[C@@H](C4=CC=C(F)C=C4)OC1
1: Desino KE, Ansar S, Georg GI, Himes RH, Michaelis ML, Powell DR, Reiff EA, Telikepalli H, Audus KL. (3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a novel neuroprotective agent. J Med Chem. 2009 Dec 10;52(23):7537-43. doi: 10.1021/jm900254k. PubMed PMID: 19728715; PubMed Central PMCID: PMC2788673.