Taladegib (LY2940680)
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205529

CAS#: 1258861-20-9

Description: Taladegib, also known LY2940680, is a potent Hedgehog inhibitor with potential anticancer activity. LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers had previously observed in patient with cancer who developed resistance to vismodegib.


Price and Availability

Size
Price

5mg
USD 110
50mg
USD 450
500mg
USD 1450
Size
Price

10mg
USD 150
100mg
USD 650
1g
USD 2250
Size
Price

25mg
USD 250
200mg
USD 950
5g
Ask price

Taladegib (LY2940680), purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 205529
Name: Taladegib (LY2940680)
CAS#: 1258861-20-9
Chemical Formula: C26H24F4N6O
Exact Mass:
Molecular Weight: 512.5
Elemental Analysis: C, 60.93; H, 4.72; F, 14.83; N, 16.40; O, 3.12


Related CAS #: 1258861-20-9 (free base)   1258861-21-0 (HCl)  

Synonym: LY2940680, LY 2940680, LY-2940680, Taladegib

IUPAC/Chemical Name: 4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide

InChi Key: SZBGQDXLNMELTB-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H24F4N6O/c1-34(25(37)20-8-7-16(27)15-21(20)26(28,29)30)17-10-13-36(14-11-17)24-19-6-4-3-5-18(19)23(32-33-24)22-9-12-31-35(22)2/h3-9,12,15,17H,10-11,13-14H2,1-2H3

SMILES Code: O=C(N(C)C1CCN(C2=NN=C(C3=CC=NN3C)C4=C2C=CC=C4)CC1)C5=CC=C(F)C=C5C(F)(F)F


Technical Data

Appearance:
White solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bai Q, Shen Y, Jin N, Liu H, Yao X. Molecular modeling study on the dynamical  structural features of human smoothened receptor and binding mechanism of antagonist LY2940680 by metadynamics simulation and free energy calculation. Biochim Biophys Acta. 2014 Mar 15. pii: S0304-4165(14)00114-7. doi: 10.1016/j.bbagen.2014.03.010. [Epub ahead of print] PubMed PMID: 24637074.