Ac32Az19

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MedKoo CAT#: 465587

CAS#: unknown

Description: Ac32Az19 is a potent, nontoxic, and highly selective BCRP inhibitor (EC50 = 1−15 nM). Ac32Az19 remarkably exhibits a 100% 5D3 shift, indicating that it can bind and cause a conformational change of BCRP. Moreover, it significantly reduces the abundance of functional BCRP dimers/oligomers by half to retain more mitoxantrone in the BCRP-overexpressing cell line and that may account for its inhibitory activity.

Chemical Structure

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Ac32Az19
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 465587
Name: Ac32Az19
CAS#: unknown
Chemical Formula: C37H33N3O6
Exact Mass: 615.24
Molecular Weight: 615.686
Elemental Analysis: C, 72.18; H, 5.40; N, 6.83; O, 15.59

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ac32Az19; Ac32 Az19; Ac32-Az19;

IUPAC/Chemical Name: methyl 3-(((2-(4-(4-(1-benzyl-1H-1,2,3-triazol-4-yl)butoxy)phenyl)-4-oxo-4H-chromen-3-yl)oxy)methyl)benzoate

InChi Key: BECCUKCZBHNIBT-UHFFFAOYSA-N

InChi Code: InChI=1S/C37H33N3O6/c1-43-37(42)29-13-9-12-27(22-29)25-45-36-34(41)32-15-5-6-16-33(32)46-35(36)28-17-19-31(20-18-28)44-21-8-7-14-30-24-40(39-38-30)23-26-10-3-2-4-11-26/h2-6,9-13,15-20,22,24H,7-8,14,21,23,25H2,1H3

SMILES Code: O=C(OC)C1=CC=CC(COC2=C(C3=CC=C(OCCCCC4=CN(CC5=CC=CC=C5)N=N4)C=C3)OC6=C(C=CC=C6)C2=O)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 615.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wong ILK, Zhu X, Chan KF, Liu Z, Chan CF, Chow TS, Chong TC, Law MC, Cui J, Chow LMC, Chan TH. Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2). J Med Chem. 2021 Oct 4. doi: 10.1021/acs.jmedchem.1c00779. Epub ahead of print. PMID: 34606270.