AC2P36

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465524

CAS#: unknown

Description: AC2P36 is a novel inhibitor of Mycobacterium tuberculosis (Mtb), selectively killing Mtb at acidic pH and potentiating the bactericidal activity of isoniazid, clofazimine, and diamide.

Chemical Structure

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AC2P36
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 465524
Name: AC2P36
CAS#: unknown
Chemical Formula: C13H11Cl2N3O4S
Exact Mass: 374.98
Molecular Weight: 376.208
Elemental Analysis: C, 41.50; H, 2.95; Cl, 18.85; N, 11.17; O, 17.01; S, 8.52

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AC2P36; AC 2P36; AC-2P36;

IUPAC/Chemical Name: 5-chloro-N-(3-chloro-4-methoxyphenyl)-2-(methylsulfonyl)pyrimidine-4-carboxamide

InChi Key: AUVGGJLRPSKQAA-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H11Cl2N3O4S/c1-22-10-4-3-7(5-8(10)14)17-12(19)11-9(15)6-16-13(18-11)23(2,20)21/h3-6H,1-2H3,(H,17,19)

SMILES Code: O=C(C1=NC(S(=O)(C)=O)=NC=C1Cl)NC2=CC=C(OC)C(Cl)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 376.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dechow SJ, Coulson GB, Wilson MW, Larsen SD, Abramovitch RB. AC2P20 selectively kills Mycobacterium tuberculosis at acidic pH by depleting free thiols. RSC Adv. 2021 Jun 4;11(33):20089-20100. doi: 10.1039/d1ra03181c. PMID: 34168865; PMCID: PMC8176622.

2: Coulson GB, Johnson BK, Zheng H, Colvin CJ, Fillinger RJ, Haiderer ER, Hammer ND, Abramovitch RB. Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics. Cell Chem Biol. 2017 Aug 17;24(8):993-1004.e4. doi: 10.1016/j.chembiol.2017.06.018. Epub 2017 Aug 3. PMID: 28781126; PMCID: PMC5562523.