PD 81723 | CAS# 132861-87-1 | Adenosine binding enhancer | A1AR PAM

PD 81723
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414815

CAS#: 132861-87-1

Description: PD 81723 is an Adenosine binding enhancer. PD-81723 is an A1AR PAM.

Chemical Structure

PD 81723

CAS# 132861-87-1

Instruction

Theoretical Analysis

MedKoo Cat#: 414815
Name: PD 81723
CAS#: 132861-87-1
Chemical Formula: C14H12F3NOS
Exact Mass: 299.06
Molecular Weight: 299.310
Elemental Analysis: C, 56.18; H, 4.04; F, 19.04; N, 4.68; O, 5.35; S, 10.71

Price and Availability

Size	Price	Availability
10mg	USD 335	2 Weeks
50mg	USD 928	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: PD 81723; PD81723; PD-81723; PD81,723; PD 81,723; PD-81,723

IUPAC/Chemical Name: Methanone, (2-amino-4,5-dimethyl-3-thienyl)(3-(trifluoromethyl)phenyl)-

InChi Key: KKDKAWKYGCUOGR-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H12F3NOS/c1-7-8(2)20-13(18)11(7)12(19)9-4-3-5-10(6-9)14(15,16)17/h3-6H,18H2,1-2H3

SMILES Code: O=C(C1=C(N)SC(C)=C1C)C2=CC=CC(C(F)(F)F)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 299.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Park SW, Kim JY, Ham A, Brown KM, Kim M, D'Agati VD, Lee HT. A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia- reperfusion injury. Am J Physiol Renal Physiol. 2012 Sep;303(5):F721-32. doi: 10.1152/ajprenal.00157.2012. Epub 2012 Jul 3. PMID: 22759398; PMCID: PMC3468496.

2: Mizumura T, Auchampach JA, Linden J, Bruns RF, Gross GJ. PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. Circ Res. 1996 Sep;79(3):415-23. doi: 10.1161/01.res.79.3.415. PMID: 8781475.

3: Kollias-Baker C, Ruble J, Dennis D, Bruns RF, Linden J, Belardinelli L. Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine. Circ Res. 1994 Dec;75(6):961-71. doi: 10.1161/01.res.75.6.961. PMID: 7955150.

4: Bhattacharya S, Linden J. The allosteric enhancer, PD 81,723, stabilizes human A1 adenosine receptor coupling to G proteins. Biochim Biophys Acta. 1995 Feb 16;1265(1):15-21. doi: 10.1016/0167-4889(94)00204-r. PMID: 7857979.

5: Meno JR, Higashi H, Cambray AJ, Zhou J, D'Ambrosio R, Winn HR. Hippocampal injury and neurobehavioral deficits are improved by PD 81,723 following hyperglycemic cerebral ischemia. Exp Neurol. 2003 Sep;183(1):188-96. doi: 10.1016/s0014-4886(03)00162-6. PMID: 12957503.

6: Musser B, Mudumbi RV, Liu J, Olson RD, Vestal RE. Adenosine A1 receptor- dependent and -independent effects of the allosteric enhancer PD 81,723. J Pharmacol Exp Ther. 1999 Feb;288(2):446-54. PMID: 9918544.

7: Mudumbi RV, Montamat SC, Bruns RF, Vestal RE. Cardiac functional responses to adenosine by PD 81,723, an allosteric enhancer of the adenosine A1 receptor. Am J Physiol. 1993 Mar;264(3 Pt 2):H1017-22. doi: 10.1152/ajpheart.1993.264.3.H1017. PMID: 8456969.

8: Phillis JW, Smith-Barbour M, Perkins LM, O'Regan MH. Characterization of glutamate, aspartate, and GABA release from ischemic rat cerebral cortex. Brain Res Bull. 1994;34(5):457-66. doi: 10.1016/0361-9230(94)90019-1. PMID: 7915962.

9: Bueters TJ, van Helden HP, Danhof M, IJzerman AP. Effects of the adenosine A1 receptor allosteric modulators PD 81,723 and LUF 5484 on the striatal acetylcholine release. Eur J Pharmacol. 2002 Nov 15;454(2-3):177-82. doi: 10.1016/s0014-2999(02)02494-9. PMID: 12421644.

10: Janusz CA, Bruns RF, Berman RF. Functional activity of the adenosine binding enhancer, PD 81,723, in the in vitro hippocampal slice. Brain Res. 1991 Dec 20;567(2):181-7. doi: 10.1016/0006-8993(91)90794-v. PMID: 1817724.

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