PD 128483

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414806

CAS#: 115688-97-6

Description: PD 128483 is a potential antipsychotic drug candidate found to be a potent frameshift mutagen.

Chemical Structure

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PD 128483
CAS# 115688-97-6
Instruction

Theoretical Analysis

MedKoo Cat#: 414806
Name: PD 128483
CAS#: 115688-97-6
Chemical Formula: C11H15N3S
Exact Mass: 221.10
Molecular Weight: 221.320
Elemental Analysis: C, 59.70; H, 6.83; N, 18.99; S, 14.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: PD 128483; PD128483; PD-128483; CCRIS4394; CCRIS-4394; CCRIS 4394

IUPAC/Chemical Name: 4,5,5a,6,7,8-Hexahydro-6-methylthiazolo(4,5-f)quinoline-2-amine

InChi Key: XFJSSDHKIXXJLM-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H15N3S/c1-14-6-2-3-7-8(14)4-5-9-10(7)13-11(12)15-9/h3,8H,2,4-6H2,1H3,(H2,12,13)

SMILES Code: NC(S1)=NC2=C1CCC3N(C)CCC=C23

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 221.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Meltzer LT, Caprathe BW, Christoffersen CL, Corbin AE, Jaen JC, Ninteman FW, Pugsley TA, Serpa KA, Shih YH, Whetzel SZ, et al. Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers. J Pharmacol Exp Ther. 1993 Sep;266(3):1177-89. PMID: 8103791.

2: Lin MY, Walters DE. The D2 autoreceptor agonists SND 919 and PD 128483 decrease stereotypy in developing rats. Life Sci. 1994;54(1):PL17-22. doi: 10.1016/0024-3205(94)00581-8. PMID: 7902951.

3: Vanover KE, Woolverton WL. Behavioral effects of the dopamine autoreceptor agonist PD 128483 alone and in combination with cocaine. J Pharmacol Exp Ther. 1994 Sep;270(3):1049-56. PMID: 7932152.

4: Lin MY, Walters DE. Dopamine D2 autoreceptors in rats are behaviorally functional at 21 but not 10 days of age. Psychopharmacology (Berl). 1994 Mar;114(2):262-8. doi: 10.1007/BF02244847. PMID: 7838918.

5: Kropko ML, Jaen JC, Theiss JC, Wold S, Caprathe BW, Wise LD. Chemical purity and mutagenicity: case study of a drug in development. Mutat Res. 1992 Apr;281(4):233-8. doi: 10.1016/0165-7992(92)90014-9. Erratum in: Mutat Res 1992 Aug;282(4):287. PMID: 1373215.