Pca 4248
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414798

CAS#: 123875-01-4

Description: Pca 4248 is a platelet activating factor antagonist.

Chemical Structure

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Pca 4248
CAS# 123875-01-4
Instruction

Theoretical Analysis

MedKoo Cat#: 414798
Name: Pca 4248
CAS#: 123875-01-4
Chemical Formula: C19H23NO4S
Exact Mass: 361.13
Molecular Weight: 361.460
Elemental Analysis: C, 63.14; H, 6.41; N, 3.88; O, 17.71; S, 8.87

Price and Availability

Size Price Availability Quantity
10mg USD 322 2 Weeks
50mg USD 828 2 Weeks
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Synonym: Pca 4248; Pca4248; Pca-4248

IUPAC/Chemical Name: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, methyl 2-(phenylthio)ethyl ester

InChi Key: DHCNAWNKZMNTIS-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H23NO4S/c1-12-16(18(21)23-4)13(2)20-14(3)17(12)19(22)24-10-11-25-15-8-6-5-7-9-15/h5-9,12,20H,10-11H2,1-4H3

SMILES Code: O=C(C1=C(C)NC(C)=C(C(OCCSC2=CC=CC=C2)=O)C1C)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 361.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Desquand S, Ruffié C, Lefort J, Hatmi M, Pina M, Priego JG, Vargaftig BB. Compound PCA-4248 interferes with bronchopulmonary anaphylaxis and with in vitro hyperresponsiveness to platelet-activating factor. Eur J Pharmacol. 1993 Apr 22;235(1):101-8. doi: 10.1016/0014-2999(93)90826-4. PMID: 7686102.

2: Fernández-Gallardo S, Ortega MP, Priego JG, de Casa-Juana MF, Sunkel C, Sánchez Crespo M. Pharmacological actions of PCA 4248, a new platelet-activating factor receptor antagonist: in vivo studies. J Pharmacol Exp Ther. 1990 Oct;255(1):34-9. PMID: 2170626.

3: Catalán RE, Martínez AM, Aragonés MD, Lombardía M, Garde E. PCA-4248, a PAF receptor antagonist, inhibits PAF-induced phosphoinositide turnover. Eur J Pharmacol. 1995 Aug 15;290(3):183-8. doi: 10.1016/0922-4106(95)00063-1. PMID: 7589212.

4: Ranasinghe S, Bolsover S. Microglial calcium responses to platelet-activating factor are inhibited by analogue CAS 99103-16-9 and dihydropyridine PCA 4248 but not by ginkgolide A. Basic Clin Pharmacol Toxicol. 2004 Aug;95(2):87-91. doi: 10.1111/j.1742-7843.2004.950208.x. PMID: 15379786.

5: Negro Alvarez JM, Miralles López JC, Ortiz Martínez JL, Abellán Alemán A, Rubio del Barrio R. Platelet-activating factor antagonists. Allergol Immunopathol (Madr). 1997 Sep-Oct;25(5):249-58. PMID: 9395010.

6: Martins MA, Lima MC, Bozza PT, Faria Neto HC, Silva PM, Sunkel CE, Cordeiro RS. Interference of the PAF receptor antagonist, PCA 4248, with the rat pleurisy evoked by inflammatory mediators or allergen. Eur J Pharmacol. 1993 Jun 11;237(1):17-22. doi: 10.1016/0014-2999(93)90087-x. PMID: 8395390.

7: Amorim CZ, Cordeiro RS, Vargaftig BB. Interference of PCA 4248, a novel PAF receptor antagonist, with antigen-induced paw edema in mice. Eur J Pharmacol. 1993 May 19;236(2):301-4. doi: 10.1016/0014-2999(93)90602-e. PMID: 8319756.

8: Ortega MP, García MC, Gijón MA, de Casa-Juana MF, Priego JG, Sanchez Crespo M, Sunkel C. 1,4-Dihydropyridines, a new class of platelet-activating factor receptor antagonists: in vitro pharmacologic studies. J Pharmacol Exp Ther. 1990 Oct;255(1):28-33. PMID: 2170624.

9: Cortés MP, Cárdenas AM, Hidalgo ME, Glena C, Fernández E, Sunkel C. New 4-alkyl-1,4-dihydropyridines: evaluation of photostability and phototoxic potential. J Photochem Photobiol B. 1993 Jul;19(2):135-8. doi: 10.1016/1011-1344(93)87108-y. PMID: 8377076.

10: Ebiike H, Maruyama K, Achiwa K. Lipase-catalyzed enantioselective hydrolysis of 4-alkyl-1,4-dihydropyridine derivatives: synthesis of (+)- and (-)-methyl 2-(phenylthio)ethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (PCA 4248). Chem Pharm Bull (Tokyo). 1992 Apr;40(4):1083-5. doi: 10.1248/cpb.40.1083. PMID: 1525941.