Partricin

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MedKoo CAT#: 414790

CAS#: 11096-49-4

Description: Partricin is a polyene antibiotic from Streptomyces aureofaciens; proposed as an antifungal & antiprotozoal agent.

Chemical Structure

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Partricin
CAS# 11096-49-4
Instruction

Theoretical Analysis

MedKoo Cat#: 414790
Name: Partricin
CAS#: 11096-49-4
Chemical Formula: C58H84N2O19
Exact Mass: 1,112.57
Molecular Weight: 1,113.310
Elemental Analysis: C, 62.57; H, 7.61; N, 2.52; O, 27.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Partricin; Spa-S132; Spa-S-132; Spa-S 132; Antibiotic spa-8-132

IUPAC/Chemical Name: (19Z,21Z,23Z,25Z,27Z,29Z,31Z)-33-(((2S,3R,4R,5R,6S)-4-amino-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-17-(7-(4-aminophenyl)-5-hydroxy-7-oxoheptan-2-yl)-1,3,5,7,9,13,37-heptahydroxy-18-methyl-11,15-dioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid

InChi Key: NVJUPMZQNWDHTL-GKTUUKTKSA-N

InChi Code: InChI=1S/C58H84N2O19/c1-34-16-14-12-10-8-6-4-5-7-9-11-13-15-17-46(77-57-54(72)52(60)53(71)36(3)76-57)31-49-51(56(73)74)48(69)33-58(75,79-49)32-45(67)28-43(65)26-41(63)24-40(62)25-42(64)27-44(66)30-50(70)78-55(34)35(2)18-23-39(61)29-47(68)37-19-21-38(59)22-20-37/h4-17,19-22,34-36,39-41,43-46,48-49,51-55,57,61-63,65-67,69,71-72,75H,18,23-33,59-60H2,1-3H3,(H,73,74)/b5-4-,8-6-,9-7-,12-10-,13-11-,16-14-,17-15-/t34?,35?,36-,39?,40?,41?,43?,44?,45?,46?,48?,49?,51?,52+,53-,54+,55?,57+,58?/m0/s1

SMILES Code: CC(C1OC(CC(CC(CC(CC(CC(CC(CC2(CC(C(C(O)=O)C(O2)CC(/C=C\C=C/C=C\C=C/C=C\C=C/C=C\C1C)O[C@H]3O[C@H]([C@@H]([C@H]([C@H]3O)N)O)C)O)O)O)O)O)O)=O)O)=O)CCC(CC(c4ccc(N)cc4)=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,113.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rimaroli C, Bonabello A, Sala P, Bruzzese T. Pharmacokinetics and tissue distribution of a new partricin A derivative (N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate) in mice. J Pharm Sci. 2002 May;91(5):1252-8. doi: 10.1002/jps.10134. PMID: 11977101.

2: Clemons KV, Stevens DA. Efficacy of the partricin derivative SPA-S-753 against systemic murine candidosis. J Antimicrob Chemother. 2001 Feb;47(2):183-6. doi: 10.1093/jac/47.2.183. PMID: 11157903.

3: Tweit RC, Pandey RC, Rinehart KL Jr. Characterization of the antifungal and antiprotozoal antibiotic partricin and structural studies on partricins A and B. J Antibiot (Tokyo). 1982 Aug;35(8):997-1012. doi: 10.7164/antibiotics.35.997. PMID: 6897240.

4: Sheehan J, Murphy CD, Caffrey P. New insights into polyene macrolide biosynthesis in Couchioplanes caeruleus. Mol Biosyst. 2017 May 2;13(5):866-873. doi: 10.1039/c7mb00112f. PMID: 28383583.

5: Luna T, Mazzolla R, Romanò G, Blasi E. Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis. Antimicrob Agents Chemother. 1997 Mar;41(3):706-8. doi: 10.1128/AAC.41.3.706. PMID: 9056019; PMCID: PMC163777.

6: Bruzzese T, Binda I, Ghielmetti G, Notarianni AF. Partricin, an antifungal and antiprotozoal polyene antibiotic. Farmaco Sci. 1974 Apr;29(4):331-4. PMID: 4208028.

7: Bruzzese T, Binda I, Di Nardo A, Ghielmetti G, Riva M. Partricin methyl ester, a semisynthetic polyene antibiotic. Experientia. 1972 Dec 15;28(12):1515-6. doi: 10.1007/BF01957888. PMID: 4631832.

8: Bruzzese T, Galmozzi MR, Buffa G, Sala P, Bonabello A. Pharmacokinetics in rats of n-dimethylaminoacetyl-partricin a 2-dimethylaminoethylamide diascorbate (spk-843). Chemotherapy. 2001 Mar-Apr;47(2):77-85. doi: 10.1159/000048504. PMID: 11173807.

9: Tarnóczi P. Metil-partricina e vaginiti. Ulteriore ricerca clinica controllata [Methyl-partricin and vaginitis. Further controlled clinical research]. Minerva Ginecol. 1976 Jul-Aug;28(7-8):643-8. Italian. PMID: 1037113.

10: Forgács J, Tarnóczy P. La metil-partricina nel trattamento delle flogosi vaginali micotico-protozoarie [Methyl-partricin in the treatment of mycotic and protozoan vaginitis]. Minerva Ginecol. 1973 Apr;25(4):210-7. Italian. PMID: 4575663.