cDPCP | CAS#106343-59-3 | DNA-crosslinking agent

cDPCP
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465410

CAS#: 106343-59-3

Description: cDPCP is a platinum-containing DNA-crosslinking agent. Unlike cisplatin or oxaliplatin, cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting proliferation of MDCK cells expressing the human transporters with IC50 values of 8.1 and 1.5 µM, respectively. cDPCP inhibits RNA polymerase II-mediated transcription in a reporter assay using HeLa cells. It increases survival in murine S180 sarcoma and P388 leukemia models when administered at doses of 40 and 80 mg/kg, respectively.

Chemical Structure

cDPCP

CAS# 106343-59-3

Instruction

Theoretical Analysis

MedKoo Cat#: 465410
Name: cDPCP
CAS#: 106343-59-3
Chemical Formula: C5H11Cl2N3Pt
Exact Mass: 378.00
Molecular Weight: 379.148
Elemental Analysis: C, 15.84; H, 2.92; Cl, 18.70; N, 11.08; Pt, 51.45

Price and Availability

Size	Price	Availability
1mg	USD 280	2 Weeks
5mg	USD 690	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: cDPCP; c DPCP; c-DPCP;

IUPAC/Chemical Name: N/A

InChi Key: JDWBOMGRVMIMAU-UHFFFAOYSA-L

InChi Code: InChI=1S/C5H5N.2ClH.2H3N.Pt/c1-2-4-6-5-3-1;;;;;/h1-5H;2*1H;2*1H3;/q;;;;;+2/p-2

SMILES Code: [Cl-][Pt+2]([N]1=CC=CC=C1)([NH3])[NH3].[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 379.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sassetti E, Durante Cruz C, Tammela P, Winterhalter M, Augustyns K, Gribbon P, Windshügel B. Identification and Characterization of Approved Drugs and Drug- Like Compounds as Covalent Escherichia coli ClpP Inhibitors. Int J Mol Sci. 2019 May 31;20(11):2686. doi: 10.3390/ijms20112686. PMID: 31159170; PMCID: PMC6600665.

2: Shao X, Xie Z, Xin Y, Yang J. A deadline constrained scheduling algorithm for cloud computing system based on the driver of dynamic essential path. PLoS One. 2019 Mar 8;14(3):e0213234. doi: 10.1371/journal.pone.0213234. PMID: 30849102; PMCID: PMC6407770.

3: Fan G, Fan M, Wang Q, Jiang J, Wan Y, Gong T, Zhang Z, Sun X. Bio-inspired polymer envelopes around adenoviral vectors to reduce immunogenicity and improve in vivo kinetics. Acta Biomater. 2016 Jan;30:94-105. doi: 10.1016/j.actbio.2015.11.005. Epub 2015 Nov 4. PMID: 26546972.

4: Ma G, Wu Q, Wu X, Arnesano F, Natile G, Sletten E, Liu Y. The reaction of a platinated methionine motif of CTR1 with cysteine and histidine is dependent upon the type of precursor platinum complex. J Inorg Biochem. 2015 Dec;153:239-246. doi: 10.1016/j.jinorgbio.2015.07.010. Epub 2015 Jul 21. PMID: 26235215.

5: Hechmi N, Ben Aissa N, Abdenaceur H, Jedidi N. Uptake and Bioaccumulation of Pentachlorophenol by Emergent Wetland Plant Phragmites australis (Common Reed) in Cadmium Co-contaminated Soil. Int J Phytoremediation. 2015;17(1-6):109-16. doi: 10.1080/15226514.2013.851169. PMID: 25237721.

6: Xu D, Min Y, Cheng Q, Shi H, Wei K, Arnesano F, Natile G, Liu Y. Chemical and cellular investigations of trans-ammine-pyridine-dichlorido-platinum(II), the likely metabolite of the antitumor active cis-diammine-pyridine-chorido- platinum(II). J Inorg Biochem. 2013 Dec;129:15-22. doi: 10.1016/j.jinorgbio.2013.07.040. Epub 2013 Aug 14. PMID: 24008133.

7: Li S, Chen Y, Zhang S, More SS, Huang X, Giacomini KM. Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis- diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice. Pharm Res. 2011 Mar;28(3):610-25. doi: 10.1007/s11095-010-0312-6. Epub 2010 Nov 23. PMID: 21104302; PMCID: PMC3040319.

8: Wang D, Zhu G, Huang X, Lippard SJ. X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9584-9. doi: 10.1073/pnas.1002565107. Epub 2010 May 6. PMID: 20448203; PMCID: PMC2906855.

9: Lovejoy KS, Todd RC, Zhang S, McCormick MS, D'Aquino JA, Reardon JT, Sancar A, Giacomini KM, Lippard SJ. cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8902-7. doi: 10.1073/pnas.0803441105. Epub 2008 Jun 25. PMID: 18579768; PMCID: PMC2449337.

10: Yuan L, Michels E, De Meester L. Changes in phototactic behavior of Daphnia magna clone C1 242 in response to copper, cadmium and pentachlorophenol. J Environ Sci (China). 2003 Nov;15(6):841-7. PMID: 14758906.

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