WHI-P154
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406121

CAS#: 211555-04-3

Description: WHI-P154 is a JAK3 inhibitor with IC50 = 1.8 μ M. WHI-P154 displays no activity at JAK1 or JAK2. WHI-P154 also Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro . Also inhibits other common kinases including EGFR (IC50 = 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K and induces apoptosis in human glioblastoma cell lines (IC50 = 158 μ M).


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
USD 2650
Size
Price

25mg
USD 250
200mg
USD 1250
2g
Ask price
Size
Price

50mg
USD 450
500mg
USD 1950
5g
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WHI-P154, purity > 98%, is in stock. The same day shipping out after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406121
Name: WHI-P154
CAS#: 211555-04-3
Chemical Formula: C16H14BrN3O3
Exact Mass: 375.02185
Molecular Weight: 376.2
Elemental Analysis: C, 51.08; H, 3.75; Br, 21.24; N, 11.17; O, 12.76


Synonym: WHIP154; WHI P154; WHIP 154; Janex1.

IUPAC/Chemical Name: 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol

InChi Key: CBIAKDAYHRWZCU-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14BrN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-13(21)11(17)5-9/h3-8,21H,1-2H3,(H,18,19,20)

SMILES Code: OC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1Br


Technical Data

Appearance:
White to grey solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Zhang H, Zhang YK, Wang YJ, Kathawala RJ, Patel A, Zhu H, Sodani K, Talele TT, Ambudkar SV, Chen ZS, Fu LW. WHI-P154 Enhances the Chemotherapeutic Effect of Anticancer Agents in ABCG2-overexpressing Cells. Cancer Sci. 2014 Jun 5. doi: 10.1111/cas.12462. [Epub ahead of print] PubMed PMID: 24903205.

2: Sareila O, Korhonen R, Kärpänniemi O, Nieminen R, Kankaanranta H, Moilanen E. Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-alpha. Int Immunopharmacol. 2008 Jan;8(1):100-8. Epub 2007 Nov 20. PubMed PMID: 18068105.

3: Sareila O, Korhonen R, Kärpänniemi O, Nieminen R, Kankaanranta H, Moilanen E. JAK inhibitors AG-490 and WHI-P154 decrease IFN-gamma-induced iNOS expression and NO production in macrophages. Mediators Inflamm. 2006;2006(2):16161. PubMed PMID: 16883061; PubMed Central PMCID: PMC1592588.

4: Richards GR, Smith AJ, Cuddon P, Ma QP, Leveridge M, Kerby J, Roderick HL, Bootman MD, Simpson PB. The JAK3 inhibitor WHI-P154 prevents PDGF-evoked process outgrowth in human neural precursor cells. J Neurochem. 2006 Apr;97(1):201-10. Epub 2006 Mar 3. PubMed PMID: 16515549.

5: Linwong W, Hirasawa N, Aoyama S, Hamada H, Saito T, Ohuchi K. Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner. Br J Pharmacol. 2005 Jul;145(6):818-28. PubMed PMID: 15852029; PubMed Central PMCID: PMC1576194.

6: Narla RK, Liu XP, Klis D, Uckun FM. Inhibition of human glioblastoma cell adhesion and invasion by 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3'-bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154). Clin Cancer Res. 1998 Oct;4(10):2463-71. PubMed PMID: 9796979.