Orgotein

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414589

CAS#: 1569268-91-2

Description: Orgotein is mainly alpha-helical partly divalent metal (Mg,Cu,Zn) chelated water soluble protein (MW-34000) from bovine liver; for treatment of cystitis; has superoxide dismutase activity.

Chemical Structure

img
Orgotein
CAS# 1569268-91-2
Instruction

Theoretical Analysis

MedKoo Cat#: 414589
Name: Orgotein
CAS#: 1569268-91-2
Chemical Formula: Cu4Zn416+
Exact Mass: 507.43
Molecular Weight: 515.690
Elemental Analysis: Cu, 49.29; Zn, 50.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Orgotein; Ontosein; Palosein

IUPAC/Chemical Name: tetracopper;tetrazinc

InChi Key: TUGDLVFMIQZYPA-UHFFFAOYSA-N

InChi Code: InChI=1S/4Cu.4Zn/q8*+2

SMILES Code: [Cu+2].[Cu+2].[Cu+2].[Cu+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 515.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Edsmyr F, Menander-Huber KB. Orgotein efficacy in ameliorating side effects due to radiation therapy. Eur J Rheumatol Inflamm. 1981;4(2):228-36. PMID: 7044789.

2: Goebel KM, Storck U, Neurath F. Intrasynovial orgotein therapy in rheumatoid arthritis. Lancet. 1981 May 9;1(8228):1015-7. doi: 10.1016/s0140-6736(81)92185-1. PMID: 6112411.

3: Esco R, Valencia J, Coronel P, Carceller JA, Gimeno M, Bascón N. Efficacy of orgotein in prevention of late side effects of pelvic irradiation: a randomized study. Int J Radiat Oncol Biol Phys. 2004 Nov 15;60(4):1211-9. doi: 10.1016/j.ijrobp.2004.04.038. PMID: 15519794.

4: Goebel KM, Storck U. Effect of intra-articular orgotein versus a corticosteroid on rheumatoid arthritis of the knees. Am J Med. 1983 Jan;74(1):124-8. doi: 10.1016/0002-9343(83)91128-2. PMID: 6336891.

5: Escribano A, García-Grande A, Montañés P, Miralles L, García A. Aerosol orgotein (Ontosein) for the prevention of radiotherapy-induced adverse effects in head and neck cancer patients: a feasibility study. Neoplasma. 2002;49(3):201-8. PMID: 12098008.

6: Cividalli A, Adami M, De Tomasi F, Palmisano L, Pardini MC, Spanò M, Mauro F. Orgotein as a radioprotector in normal tissues. Experiments on mouse skin and a murine adenocarcinoma. Acta Radiol Oncol. 1985 May-Jun;24(3):273-7. doi: 10.3109/02841868509134400. PMID: 2994380.

7: Gammer W, Brobäck LG. Clinical comparison of orgotein and methylprednisolone acetate in the treatment of osteoarthrosis of the knee joint. Scand J Rheumatol. 1984;13(2):108-12. doi: 10.3109/03009748409100372. PMID: 6377491.

8: Huber W. Orgotein--(bovine Cu-Zn superoxide dismutase), an anti-inflammatory protein drug: discovery, toxicology and pharmacology. Eur J Rheumatol Inflamm. 1981;4(2):173-82. PMID: 7343319.

9: Menander-Huber KB, Edsmyr F, Huber W. Orgotein (superoxide dismutase): a drug for the amelioration of radiation-induced side effects. A double-blind, placebo- controlled study in patients with bladder tumours. Urol Res. 1978;6(4):255-7. doi: 10.1007/BF00262630. PMID: 105443.

10: Cushing LS, Decker WE, Santos FK, Schulte TL, Huber W. Orgotein therapy for inflammation in horses. Mod Vet Pract. 1973 Jul;54(7):17-21. PMID: 4736630.