Estriol succinate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414548

CAS#: 514-68-1 (succinate)

Description: Estriol succinate, sold under the brand name Synapause among others, is an estrogen medication which is used in the treatment of menopausal symptoms. It is taken by mouth, in through the vagina, and by injection.

Chemical Structure

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Estriol succinate
CAS# 514-68-1 (succinate)
Instruction

Theoretical Analysis

MedKoo Cat#: 414548
Name: Estriol succinate
CAS#: 514-68-1 (succinate)
Chemical Formula: C26H32O9
Exact Mass: 488.20
Molecular Weight: 488.530
Elemental Analysis: C, 63.92; H, 6.60; O, 29.47

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 514-68-1 (succinate); 50-27-1 (free base)  

Synonym: Estriol succinate; Estrioli succinas; Oestriol succinate

IUPAC/Chemical Name: 4,4'-(((8R,9S,13S,14S,16R,17R)-3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-16,17-diyl)bis(oxy))bis(4-oxobutanoic acid)

InChi Key: VBRVDDFOBZNCPF-BRSFZVHSSA-N

InChi Code: InChI=1S/C26H32O9/c1-26-11-10-17-16-5-3-15(27)12-14(16)2-4-18(17)19(26)13-20(34-23(32)8-6-21(28)29)25(26)35-24(33)9-7-22(30)31/h3,5,12,17-20,25,27H,2,4,6-11,13H2,1H3,(H,28,29)(H,30,31)/t17-,18-,19+,20-,25+,26+/m1/s1

SMILES Code: C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@H]([C@@H]2OC(CCC(O)=O)=O)OC(CCC(O)=O)=O)CCc4c3ccc(O)c4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 488.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: VAN VEENJ. LE SUCCINATE D'OESTRIOL DANS LE TRAITEMENT DES DIATH'ESES H'EMORRAGIQUES [ESTRIOL SUCCINATE IN THE TREATMENT OF HEMORRHAGIC DIATHESES]. Hormoner. 1963;16:1-15. French. PMID: 14064055.

2: Lee JA, Damianov A, Lin CH, Fontes M, Parikshak NN, Anderson ES, Geschwind DH, Black DL, Martin KC. Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes. Neuron. 2016 Jan 6;89(1):113-28. doi: 10.1016/j.neuron.2015.11.025. Epub 2015 Dec 10. PMID: 26687839; PMCID: PMC4858412.

3: Zhu H, Zhang W, Zhao Y, Shu X, Wang W, Wang D, Yang Y, He Z, Wang X, Ying Y. GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions. Mol Neurodegener. 2018 Nov 22;13(1):62. doi: 10.1186/s13024-018-0295-z. PMID: 30466464; PMCID: PMC6251088.

4: Punnonen R, Söderström KO. The effect of oral estriol succinate therapy on the endometrial morphology in postmenopausal women: the significance of fractionation of the dose. Eur J Obstet Gynecol Reprod Biol. 1983 Jan;14(4):217-24. doi: 10.1016/0028-2243(83)90263-0. PMID: 6832445.

5: Lauritzen C. Results of a 5 years prospective study of estriol succinate treatment in patients with climacteric complaints. Horm Metab Res. 1987 Nov;19(11):579-84. doi: 10.1055/s-2007-1011886. PMID: 3428874.

6: Cabrera J, Canahuate E, del Campo SL, Poloni O, Ramírez SI. Respuesta citológica de la vagina irradiada al succinato de estriol [Cytologic response of the irradiated vagina to estriol succinate]. Rev Chil Obstet Ginecol. 1993;58(4):317-22. Spanish. PMID: 7991851.

7: Yang TS, Tsan SH, Chang SP, Ng HT. Efficacy and safety of estriol replacement therapy for climacteric women. Zhonghua Yi Xue Za Zhi (Taipei). 1995 May;55(5):386-91. PMID: 7641124.

8: Ueno M. [Microglia in Brain Development]. Brain Nerve. 2017 Sep;69(9):985-997. Japanese. doi: 10.11477/mf.1416200858. PMID: 28900061.

9: Berger A, Meissl G. Klinische Erfahrungen mit Ostriolsuccinat bei handchirurgischen Eingriffen [Clinical experiences with estriol succinate in surgery of the hand]. Wien Klin Wochenschr. 1970 Aug 14;82(33):582-3. German. PMID: 5514325.

10: Romero-Salinas, Quiróz-Jiménez. El succinato de estriol y su efecto sobre la contractilidad del útero humano durante el climaterio [Estriol succinate and its effect on the contractility of the human uterus during the climateric]. Ginecol Obstet Mex. 1978 Apr;43(258):269-78. Spanish. PMID: 689426.