Vandetanib
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 203100

CAS#: 443913-73-3

Description: Vandetanib is an orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis. Vandetanib was the first drug to be approved by FDA (April 2011) for treatment of late-stage (metastatic) medullary thyroid cancer in adult patients who are ineligible for surgery. Vandetanib was approved in 2011.


Price and Availability

Size
Price

25mg
USD 90
200mg
USD 350
2g
USD 950
Size
Price

50mg
USD 150
500mg
USD 450
5g
USD 1650
Size
Price

100mg
USD 250
1g
USD 550

Vandetanib, purity > 98%, is in stock. The same day shipping out after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Note: the estimated shipping out time for order > 2g may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 203100
Name: Vandetanib
CAS#: 443913-73-3
Chemical Formula: C22H24BrFN4O2
Exact Mass: 474.10667
Molecular Weight: 475.35
Elemental Analysis: C, 55.59; H, 5.09; Br, 16.81; F, 4.00; N, 11.79; O, 6.73


Synonym: AZD6474; AZD 6474; AZD-6474; ZD6474; ZD 6474; ZD-6474; CHEBI:38942; Vandetanib; Zactim; Caprelsa

IUPAC/Chemical Name: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

InChi Key: UHTHHESEBZOYNR-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)

SMILES Code: CN1CCC(COC2=CC3=NC=NC(NC4=CC=C(Br)C=C4F)=C3C=C2OC)CC1


Technical Data

Appearance:
Light yellow to yellow solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Vandetanib is being developed by AstraZeneca. In April 2011, Vandetanib became the first drug to be approved by FDA for treatment of late-stage (metastatic) medullary thyroid cancer in adult patients who are ineligible for surgery. Vandetanib was first initially marketed without a tradename, and is being marketed under the trade name Caprelsa since August 2011. (source: http://en.wikipedia.org/wiki/ Vandetanib ).
 
Vandetanib is also  a medication currently undergoing clinical trials as a potential targeted treatment for non-small-cell lung cancer. There have been some promising results from a phase III trial with docetaxel.  There have also been ambivalent results when used with pemetrexed. Another trial with docetaxel was recruiting in July 2009. AstraZeneca withdrew EU regulatory submissions for Zactima in October 2009 after trials showed no benefit when the drug was administered alongside chemotherapy. (source: http://en.wikipedia.org/wiki/ Vandetanib ).
 
 
 


References

1: Duplomb S, Benoit A, Mechtouff-Cimarelli L, Cho TH, Derbel O, Peix JL, de la Fouchardière C. Unusual Adverse Event With Vandetanib in Metastatic Medullary Thyroid Cancer. J Clin Oncol. 2011 Dec 12. [Epub ahead of print] PubMed PMID: 22162581.

2: Langmuir PB, Yver A. Vandetanib for the Treatment of Thyroid Cancer. Clin Pharmacol Ther. 2011 Dec 7. doi: 10.1038/clpt.2011.272. [Epub ahead of print] PubMed PMID: 22158569.

3: Ernesto S, Arpin D, Nesme P, Pérol M. Diffuse Interstitial Lung Disease Linked to Vandetanib. Clin Lung Cancer. 2011 Nov 29. [Epub ahead of print] PubMed PMID: 22133289.

4: Koch L. Pharmacotherapy: Vandetanib-a new therapeutic option in advanced medullary thyroid cancer. Nat Rev Endocrinol. 2011 Nov 15;8(1):1. doi: 10.1038/nrendo.2011.198. PubMed PMID: 22083086.

5: Solomon B, Rischin D. Progress in Molecular Targeted Therapy for Thyroid Cancer: Vandetanib in Medullary Thyroid Cancer. J Clin Oncol. 2011 Oct 24. [Epub ahead of print] PubMed PMID: 22025155.

6: Wells SA Jr, Robinson BG, Gagel RF, Dralle H, Fagin JA, Santoro M, Baudin E, Elisei R, Jarzab B, Vasselli JR, Read J, Langmuir P, Ryan AJ, Schlumberger MJ. Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial. J Clin Oncol. 2011 Nov 21. [Epub ahead of print] PubMed PMID: 22025146.

7: Qi WX, Tang LN, He AN, Shen Z, Yao Y. The role of vandetanib in the second-line treatment for advanced non-small-cell-lung cancer: a meta-analysis of four randomized controlled trials. Lung. 2011 Dec;189(6):437-43. Epub 2011 Oct 11. PubMed PMID: 21986852.

8: Ahn J, Wee WR, Lee JH, Hyon JY. Vortex keratopathy in a patient receiving vandetanib for non-small cell lung cancer. Korean J Ophthalmol. 2011 Oct;25(5):355-7. Epub 2011 Sep 20. PubMed PMID: 21976946; PubMed Central PMCID: PMC3178773.

9: Giovannetti E, Zucali PA, Assaraf YG, Leon LG, Smid K, Alecci C, Giancola F, Destro A, Gianoncelli L, Lorenzi E, Roncalli M, Santoro A, Peters GJ. Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin. Br J Cancer. 2011 Nov 8;105(10):1542-53. doi: 10.1038/bjc.2011.400. Epub 2011 Oct 4. PubMed PMID: 21970874.

10: Saletti P, Sessa C, De Dosso S, Cerny T, Renggli V, Koeberle D. Phase I dose-finding study of vandetanib in combination with gemcitabine in locally advanced unresectable or metastatic pancreatic adenocarcinoma. Oncology. 2011;81(1):50-4. Epub 2011 Sep 15. PubMed PMID: 21921646.