SU14813
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 202710

CAS#: 627908-92-3 (free base)

Description: SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), KIT, and fms-like tyrosine kinase 3 (FLT-3) (1). SU14813 was developed as a next-generation TKI agent following sunitinib (SU11248) designed to demonstrate optimized pharmacokinetic (PK) and tolerability profiles. SU14813 demonstrated broad and potent antitumor activity equivalent to that of sunitinib, which resulted in tumor regression, growth arrest, growth delay, and prolonged survival in established xenograft cancer models in mice.


Price and Availability

Size
Price

10mg
USD 90
100mg
USD 450
1g
USD 2050
Size
Price

25mg
USD 150
200mg
USD 650
2g
USD 3950
Size
Price

50mg
USD 250
500mg
USD 1250
5g
Ask price

SU14813, purity > 98%, is in stock. The same day shipping out after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 202710
Name: SU14813
CAS#: 627908-92-3 (free base)
Chemical Formula: C23H27FN4O4
Exact Mass: 442.20163
Molecular Weight: 442.48
Elemental Analysis: C, 62.43; H, 6.15; F, 4.29; N, 12.66; O, 14.46


Synonym: SU14813; SU 14813; SU-14813; SU014813; SU-014813; SU 014813

IUPAC/Chemical Name: (S,Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-N-(2-hydroxy-3-morpholinopropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

SMILES Code: O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(F)C=C3)=O)=C1C)NC[C@H](O)CN4CCOCC4


Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Related CAS#
452105-23-6 ( SU14813 double Z isomer)
627908-92-3 (SU1481free base);
849643-15-8 (SU1481 maleate)
   
         
      
       
       


References