Fluperamide HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414391

CAS#: 34552-82-4 (HCl)

Description: Fluperamide HCl is an antidiarrheal agent

Chemical Structure

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Fluperamide HCl
CAS# 34552-82-4 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 414391
Name: Fluperamide HCl
CAS#: 34552-82-4 (HCl)
Chemical Formula: C30H33Cl2F3N2O2
Exact Mass: 0.00
Molecular Weight: 581.500
Elemental Analysis: C, 61.97; H, 5.72; Cl, 12.19; F, 9.80; N, 4.82; O, 5.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 34552-82-4 (HCl); 53179-10-5 (free base)  

Synonym: Fluperamide hydrochloride; Fluperamide HCl; NIH 8636; NIH 8715; UM 866; UM 900

IUPAC/Chemical Name: 1-Piperidinebutanamide, 4-(4-chloro-3-(trifluoromethyl)phenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-, monohydrochloride

InChi Key: GEWHMNRKXIVZJF-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H32ClF3N2O2.ClH/c1-35(2)27(37)29(22-9-5-3-6-10-22,23-11-7-4-8-12-23)17-20-36-18-15-28(38,16-19-36)24-13-14-26(31)25(21-24)30(32,33)34;/h3-14,21,38H,15-20H2,1-2H3;1H

SMILES Code: O=C(N(C)C)C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3CCC(O)(C4=CC=C(Cl)C(C(F)(F)F)=C4)CC3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 581.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Megens AA, Canters LL, Awouters FH, Niemegeers CJ. Normalization of small
intestinal propulsion with loperamide-like antidiarrheals in rats. Eur J
Pharmacol. 1990 Mar 27;178(3):357-64. PubMed PMID: 2340864.


2: Reynolds IJ, Gould RJ, Snyder SH. Loperamide: blockade of calcium channels as
a mechanism for antidiarrheal effects. J Pharmacol Exp Ther. 1984
Dec;231(3):628-32. PubMed PMID: 6502516.


3: Farrington H, Mendelsohn F, Chan S, Reinlib L, Guggino SE. Strychnine-binding
proteins in intestinal cells: novel brucine binding site with binding affinities
for alkaloids. J Pharmacol Exp Ther. 1994 Nov;271(2):1074-9. PubMed PMID:
7525935.