Glasdegib (PF-04449913)
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205582

CAS#: 1095173-27-5

Description: Glasdegib, also known as PF-04449913, is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. Hedgehog inhibitor PF-04449913 appears to inhibit Hh pathway signaling. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Constitutive activation of Hh pathway signaling has been observed in various types of malignancies.


Price and Availability

Size
Price

5mg
USD 170
50mg
USD 750
500mg
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Size
Price

10mg
USD 250
100mg
USD 1250
1g
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Size
Price

25mg
USD 450
200mg
USD 1750
2g
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Glasdegib (PF04449913), purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 200mg may be 2 months.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 205582
Name: Glasdegib (PF-04449913)
CAS#: 1095173-27-5
Chemical Formula: C21H22N6O
Exact Mass: 374.18551
Molecular Weight: 374.44
Elemental Analysis: C, 67.36; H, 5.92; N, 22.44; O, 4.27


Synonym: PF04449913; PF-04449913; PF 04449913; PF4449913; PF-4449913; PF 4449913; Glasdegib.

IUPAC/Chemical Name: 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea

InChi Key: SFNSLLSYNZWZQG-VQIMIIECSA-N

InChi Code: InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1

SMILES Code: O=C(NC1=CC=C(C#N)C=C1)N[C@H]2C[C@H](C3=NC4=CC=CC=C4N3)N(C)CC2


Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

 
 


References

1.Methods of determining combinations comprising interleukin-2 (IL-2) and targeted chemotherapeutics for the treatment of cancer By Gong, Hua From PCT Int. Appl. (2013), WO 2013044169 A1 20130328.