Elapegademase

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414187

CAS#: 1709806-75-6

Description: Elapegademase is an Adenosine Deaminase Inhibitor

Chemical Structure

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Elapegademase
CAS# 1709806-75-6
Instruction

Theoretical Analysis

MedKoo Cat#: 414187
Name: Elapegademase
CAS#: 1709806-75-6
Chemical Formula: C10H20N2O5
Exact Mass: 248.14
Molecular Weight: 248.280
Elemental Analysis: C, 48.38; H, 8.12; N, 11.28; O, 32.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Elapegademase; EZN2279; EZN 2279; EZN-2279

IUPAC/Chemical Name: N6-((2-methoxyethoxy)carbonyl)-L-lysine

InChi Key: XNGDIOBPVDBNQH-QMMMGPOBSA-N

InChi Code: InChI=1S/C10H20N2O5/c1-16-6-7-17-10(15)12-5-3-2-4-8(11)9(13)14/h8H,2-7,11H2,1H3,(H,12,15)(H,13,14)/t8-/m0/s1

SMILES Code: COCCOC(NCCCC[C@@H](C(O)=O)N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 248.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Elapegademase. 2020 Jul 20. PMID: 32697455.

2: Murguia-Favela L, Min W, Loves R, Leon-Ponte M, Grunebaum E. Comparison of elapegademase and pegademase in ADA-deficient patients and mice. Clin Exp Immunol. 2020 May;200(2):176-184. doi: 10.1111/cei.13420. Epub 2020 Feb 9. PMID: 31989577; PMCID: PMC7160653.

3: Kim DH, Lee HS, Kwon TW, Han YM, Kang NW, Lee MY, Kim DD, Kim MG, Lee JY. Single enzyme nanoparticle, an effective tool for enzyme replacement therapy. Arch Pharm Res. 2020 Jan;43(1):1-21. doi: 10.1007/s12272-020-01216-3. Epub 2020 Jan 27. PMID: 31989476.