K145 HCl salt
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406275

CAS#: 1449240-68-9 (HCl)

Description: K145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent. K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30±0.06 µM. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells. K145 exhibits comparable in vivo anti-tumor activity to tamibarotene, while concomitantly exhibiting less toxicity in this U937 xenograft cancer model.


Price and Availability

Size
Price

5mg
USD 90
50mg
USD 450
500mg
USD 2250
Size
Price

10mg
USD 150
100mg
USD 850
1g
USD 3650
Size
Price

25mg
USD 250
200mg
USD 1350
5g
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K145 HCl salt, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 1g may be 1 months.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406275
Name: K145 HCl salt
CAS#: 1449240-68-9 (HCl)
Chemical Formula: C18H24N2O3S
Exact Mass: 348.15076
Molecular Weight: 348.46
Elemental Analysis: C, 62.04; H, 6.94; N, 8.04; O, 13.77; S, 9.20


Synonym: K145; K-145; K 145; K145 HCl; K145 hydrochloride.

IUPAC/Chemical Name: (Z)-3-(2-aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione hydrochloride

InChi Key: HADFDMGQKBGVAV-NKBLJONXSA-N

InChi Code: InChI=1S/C18H24N2O3S.ClH/c1-2-3-13-23-15-9-7-14(8-10-15)5-4-6-16-17(21)20(12-11-19)18(22)24-16;/h6-10H,2-5,11-13,19H2,1H3;1H/b16-6-;

SMILES Code: O=C(N(CCN)C/1=O)SC1=C/CCC2=CC=C(OCCCC)C=C2.[H]Cl


Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, and in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO or water.

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

 Related CAS#:
CAS#1449240-68-9 (K145 HCl salt);
CAS#1309444-75-4 (K145 free base) 
 
 
 


References

 1: Liu K, Guo TL, Hait NC, Allegood J, Parikh HI, Xu W, Kellogg GE, Grant S, Spiegel S, Zhang S. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent. PLoS One. 2013;8(2):e56471. doi: 10.1371/journal.pone.0056471. Epub 2013 Feb 20. PubMed PMID: 23437140; PubMed Central PMCID: PMC3577900.