Isbufylline

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576784

CAS#: 90162-60-0

Description: Isbufylline is a xanthine derivative with antibronchospastic activity.

Chemical Structure

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Isbufylline
CAS# 90162-60-0
Instruction

Theoretical Analysis

MedKoo Cat#: 576784
Name: Isbufylline
CAS#: 90162-60-0
Chemical Formula: C11H16N4O2
Exact Mass: 236.13
Molecular Weight: 236.270
Elemental Analysis: C, 55.92; H, 6.83; N, 23.71; O, 13.54

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Isbufylline

IUPAC/Chemical Name: 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(2-methylpropyl)-

InChi Key: WHUWQSQEVISUMC-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H16N4O2/c1-7(2)5-15-6-12-9-8(15)10(16)14(4)11(17)13(9)3/h6-7H,5H2,1-4H3

SMILES Code: CC(C)Cn1cnc2N(C)C(=O)N(C)C(=O)c12

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 236.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Manzini S, Perretti F, Abelli L, Evangelista S, Seeds EA, Page CP. Isbufylline, a new xanthine derivative, inhibits airway hyperresponsiveness and airway inflammation in guinea pigs. Eur J Pharmacol. 1993 Nov 16;249(3):251-7. doi: 10.1016/0014-2999(93)90519-n. PMID: 7507057.

2. Manzini S, Meini S, Giachetti A, Beani L, Borea PA, Antonelli T, Ballati L, Bacciarelli C. Pharmacodynamic profile of isbufylline, a new antibronchospastic xanthine devoid of central excitatory actions. Arzneimittelforschung. 1990 Nov;40(11):1205-13. PMID: 1707621.

3. Meini S, Ballati L, Evangelista S, Manzini S. Isbufylline, a xanthine derivative, inhibits bronchoconstrictor responses produced by stimulation of capsaicin-sensitive sensory nerves in guinea-pig: 'In vitro' and 'in vivo' evidence. Pulm Pharmacol. 1993 Dec;6(4):279-86. doi: 10.1006/pulp.1993.1037. PMID: 7511949.

4. Agostini O, Bonacchi G, Coppini G, Toja E, Triolo A, Manzini S, Pieraccini G, Moneti G. Metabolism of isbufylline in humans. Isolation, identification, and synthesis of plasma and urine metabolites. Drug Metab Dispos. 1994 Mar-Apr;22(2):259-68. PMID: 7516853.