IS-741 calcium

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576775

CAS#: 141284-77-7

Description: IS-741 calcium is a phospholipase A2 inhibitor.

Chemical Structure

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IS-741 calcium
CAS# 141284-77-7
Instruction

Theoretical Analysis

MedKoo Cat#: 576775
Name: IS-741 calcium
CAS#: 141284-77-7
Chemical Formula: C30H38CaF6N6O6S2
Exact Mass: 796.18
Molecular Weight: 796.860
Elemental Analysis: C, 45.22; H, 4.81; Ca, 5.03; F, 14.30; N, 10.55; O, 12.05; S, 8.05

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: IS-741 calcium; IS 741 calcium; IS741 calcium

IUPAC/Chemical Name: Cyclohexanecarboxamide, N-(2-((ethylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-, calcium salt (2:1)

InChi Key: FVXSTPVMJKSRNB-UHFFFAOYSA-L

InChi Code: InChI=1S/2C15H20F3N3O3S.Ca/c2*1-2-25(23,24)21-13-12(8-11(9-19-13)15(16,17)18)20-14(22)10-6-4-3-5-7-10;/h2*8-10H,2-7H2,1H3,(H2,19,20,21,22);/q;;+2/p-2

SMILES Code: [Ca+2].CCS(=O)(=O)Nc1ncc(cc1[N-]C(=O)C2CCCCC2)C(F)(F)F.CCS(=O)(=O)Nc3ncc(cc3[N-]C(=O)C4CCCCC4)C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 796.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Garcia-Garcia HM, Serruys PW. Phospholipase A2 inhibitors. Curr Opin Lipidol. 2009 Aug;20(4):327-32. doi: 10.1097/MOL.0b013e32832dd4c7. Review. PubMed PMID: 19550325.

2: Farooqui AA, Ong WY, Horrocks LA. Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders. Pharmacol Rev. 2006 Sep;58(3):591-620. Review. PubMed PMID: 16968951.

3: Meyer MC, Rastogi P, Beckett CS, McHowat J. Phospholipase A2 inhibitors as potential anti-inflammatory agents. Curr Pharm Des. 2005;11(10):1301-12. Review. PubMed PMID: 15853686.