DS 4574

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413940

CAS#: 118314-35-5

Description: DS 4574 is a peptidoleukotriene receptor antagonist used in treatment of hypersensitivity.

Chemical Structure

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DS 4574
CAS# 118314-35-5
Instruction

Theoretical Analysis

MedKoo Cat#: 413940
Name: DS 4574
CAS#: 118314-35-5
Chemical Formula: C13H16N6OS
Exact Mass: 304.11
Molecular Weight: 304.370
Elemental Analysis: C, 51.30; H, 5.30; N, 27.61; O, 5.26; S, 10.53

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: DS 4574; DS4574; DS 4574

IUPAC/Chemical Name: (1,3,4)Thiadiazolo(3,2-a)-1,2,3-triazolo(4,5-d)pyrimidin-9(1H)-one, 6-(2-cyclohexylethyl)-

InChi Key: ASIFEXZWAKYMRM-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H16N6OS/c20-12-10-11(16-18-15-10)14-13-19(12)17-9(21-13)7-6-8-4-2-1-3-5-8/h8H,1-7H2,(H,15,16,18)

SMILES Code: O=C1C(NN=N2)=C2N=C3N1N=C(CCC4CCCCC4)S3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 304.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Aibara S, Mori M, Iwamoto T, Chiba T, Tsukada W. Antagonistic action of DS-4574 against leukotrienes in guinea-pig smooth muscle. Arch Int Pharmacodyn Ther. 1991 Nov-Dec;314:147-59. PMID: 1668601.

2: Aibara S, Mori M, Tsukada W. Inhibitory effect of DS-4574 on leukotriene- or antigen-induced bronchoconstriction in guinea pigs. Int Arch Allergy Immunol. 1993;100(3):268-73. doi: 10.1159/000236423. PMID: 7680929.

3: Tabuchi Y, Kurebayashi Y. Effect of DS-4574, a novel peptidoleukotriene antagonist with mast cell stabilizing action, on acute gastric lesions and gastric secretion in rats. Jpn J Pharmacol. 1992 Dec;60(4):335-40. doi: 10.1254/jjp.60.335. PMID: 1287268.

4: Aibara S, Mori M, Iwamoto T, Tsubokawa M, Takamori H, Tsukada W. Effects of DS-4574, a new orally active antiallergic agent, in experimental allergic and inflammatory models. Jpn J Pharmacol. 1993 Apr;61(4):267-76. doi: 10.1254/jjp.61.267. PMID: 8320873.

5: Tabuchi Y, Kawarabayashi K, Furuhama K. Inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on compound 48/80-induced gastric mucosal lesions in rats. Agents Actions. 1994 Mar;41(1-2):21-4. doi: 10.1007/BF01986388. PMID: 7521568.

6: Yamashika Y, Tabuchi Y, Kokue E. Antisecretory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene antagonism, on gastric acid secretion in the pig. Agents Actions. 1994 Mar;41(1-2):17-20. doi: 10.1007/BF01986387. PMID: 8079817.

7: Tabuchi Y, Furuhama K. Inhibitory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene receptor antagonism, on gastric acid secretion in rats. Eur J Pharmacol. 1994 Apr 1;255(1-3):229-34. doi: 10.1016/0014-2999(94)90102-3. PMID: 8026547.

8: Aibara S, Mori M, Tsubokawa M, Iwamoto T, Tsukada W. Antiallergic activity of 6-(2-cyclohexylethyl)-[1,3,4]thiadiazolo- [3,2-a]-1,2,3-triazolo-[4,5-d]pyrimidin-9(3H)-one (DS-4574) in rats. Int Arch Allergy Immunol. 1992;98(2):146-52. doi: 10.1159/000236178. PMID: 1379506.

9: Tabuchi Y, Kawarabayashi K, Komada T, Furuhama K. Protective effect of DS-4574 on gastric mucosal injury induced by acidified ethanol in rats. Eur J Pharmacol. 1993 Nov 30;250(1):197-9. doi: 10.1016/0014-2999(93)90644-w. PMID: 7907021.

10: Murayama N, Nakaoka M, Nomura H, Hakusui H. Radioimmunoassay for DS-4574, an antiallergic agent: development, evaluation, and application to human plasma samples. J Pharm Sci. 1994 Nov;83(11):1574-7. doi: 10.1002/jps.2600831111. PMID: 7891277.