NAMI-A
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206020

CAS#: 201653-76-1

Description: NAMI-A is a ruthenium anticancer agent and a metastasis inhibitor. NAMI is an acronym for "New Anti-tumour Metastasis Inhibitor", while the -A suffix indicates that this is the first of a potential series. NAMI-A is a potent agent for the treatment of solid tumor metastases as well as when these tumor lesions are in an advanced stage of growth. NAMI-A is endowed with a mechanism of action unrelated to direct tumor cell cytotoxicity, and such mechanism of action is responsible for a reduced host toxicity. NAMI-A and KP-1019 are two ruthenium anticancer agents that have entered clinical trials. (http://en.wikipedia.org/wiki/NAMI-A).


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2g
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NAMI-A is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206020
Name: NAMI-A
CAS#: 201653-76-1
Chemical Formula: C8H15Cl4N4ORuS
Exact Mass:
Molecular Weight: 458.18
Elemental Analysis: C, 20.97; H, 3.30; Cl, 30.95; N, 12.23; O, 3.49; Ru, 22.06; S, 7.00


Synonym: NAMIA; ImH-trans-RuCl4(DMSO)-Im; imidazolium transimidazoledimethyl sulfoxidetetrachlororuthenat.

IUPAC/Chemical Name: Ruthenate(1-), tetrachloro(1H-imidazole-κN3)[(sulfinyl-κS)bis[methane]]-, (OC-6-11)-, hydrogen, compd. with 1H-imidazole (1:1:1).

SMILES Code: Cl[Ru]([N]1=CNC=C1)(Cl)(Cl)(Cl)=S(C)(C)=O.C2=C[NH+]=CN2


Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Novohradský V, Bergamo A, Cocchietto M, Zajac J, Brabec V, Mestroni G, Sava G. Influence of the binding of reduced NAMI-A to human serum albumin on the pharmacokinetics and biological activity. Dalton Trans. 2014 Dec 23;44(4):1905-13. doi: 10.1039/c4dt02865a. PubMed PMID: 25489765.

2: Leijen S, Burgers SA, Baas P, Pluim D, Tibben M, van Werkhoven E, Alessio E, Sava G, Beijnen JH, Schellens JH. Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy. Invest New Drugs. 2015 Feb;33(1):201-14. doi: 10.1007/s10637-014-0179-1. Epub 2014 Oct 25. PubMed PMID: 25344453.

3: Bergamo A, Riedel T, Dyson PJ, Sava G. Preclinical combination therapy of the investigational drug NAMI-A(+) with doxorubicin for mammary cancer. Invest New Drugs. 2015 Feb;33(1):53-63. doi: 10.1007/s10637-014-0175-5. Epub 2014 Oct 23. PubMed PMID: 25338748.

4: Adigun RA, Martincigh B, Nyamori VO, Omondi B, Masimirembwa C, Simoyi RH. Kinetics and mechanistic investigation into the possible activation of imidazolium trans-[tetrachloridodimethylsulfoxideimidazoleruthenate(III)], NAMI-A, by 2-mercaptoethane sulfonate. Dalton Trans. 2014 Sep 14;43(34):12943-51. doi: 10.1039/c4dt01643b. PubMed PMID: 25026023.

5: Pillozzi S, Gasparoli L, Stefanini M, Ristori M, D'Amico M, Alessio E, Scaletti F, Becchetti A, Arcangeli A, Messori L. NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels. Dalton Trans. 2014 Aug 28;43(32):12150-5. doi: 10.1039/c4dt01356e. PubMed PMID: 24975719.

6: Messori L, Merlino A. Ruthenium metalation of proteins: the X-ray structure of the complex formed between NAMI-A and hen egg white lysozyme. Dalton Trans. 2014 Apr 28;43(16):6128-31. doi: 10.1039/c3dt53582g. PubMed PMID: 24553967.

7: Sooriyaarachchi M, Wedding JL, Harris HH, Gailer J. Simultaneous observation of the metabolism of cisplatin and NAMI-A in human plasma in vitro by SEC-ICP-AES. J Biol Inorg Chem. 2014 Aug;19(6):1049-53. doi: 10.1007/s00775-014-1102-0. Epub 2014 Jan 24. PubMed PMID: 24458238.

8: Vadori M, Pacor S, Vita F, Zorzet S, Cocchietto M, Sava G. Features and full reversibility of the renal toxicity of the ruthenium-based drug NAMI-A in mice. J Inorg Biochem. 2013 Jan;118:21-7. doi: 10.1016/j.jinorgbio.2012.09.018. Epub 2012 Sep 26. PubMed PMID: 23123335.

9: Mazuryk O, Kurpiewska K, Lewiński K, Stochel G, Brindell M. Interaction of apo-transferrin with anticancer ruthenium complexes NAMI-A and its reduced form. J Inorg Biochem. 2012 Nov;116:11-8. doi: 10.1016/j.jinorgbio.2012.07.017. Epub 2012 Jul 29. PubMed PMID: 23010324.

10: Aitken JB, Antony S, Weekley CM, Lai B, Spiccia L, Harris HH. Distinct cellular fates for KP1019 and NAMI-A determined by X-ray fluorescence imaging of single cells. Metallomics. 2012 Oct;4(10):1051-6, 1007. Epub 2012 Aug 20. PubMed PMID: 22907648.