GDC-0310
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MedKoo CAT#: 464277

CAS#: 1788063-52-4

Description: GDC-0310 is a selective Nav1.7 inhibitor (EC50,u of 3.5 nM). GDC-0310 showed improved permeability inMDCK cells and increased kinetic solubility. GDC-0310 showed substantially improved Nav selectivity and ADME properties.

Chemical Structure

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GDC-0310
CAS# 1788063-52-4
Instruction

Theoretical Analysis

MedKoo Cat#: 464277
Name: GDC-0310
CAS#: 1788063-52-4
Chemical Formula: C25H29Cl2FN2O4S
Exact Mass: 542.12
Molecular Weight: 543.475
Elemental Analysis: C, 55.25; H, 5.38; Cl, 13.05; F, 3.50; N, 5.15; O, 11.78; S, 5.90

Price and Availability

Size Price Availability Quantity
5mg USD 850 2 Weeks
10mg USD 1450 2 Weeks
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Synonym: GDC-0310; GDC0310; GDC 0310;

IUPAC/Chemical Name: (S)-5-cyclopropyl-4-((1-(1-(3,5-dichlorophenyl)ethyl)piperidin-4-yl)methoxy)-2-fluoro-N-(methylsulfonyl)benzamide

InChi Key: SXOAHIZWCZOILH-HNNXBMFYSA-N

InChi Code: InChI=1S/C25H29Cl2FN2O4S/c1-15(18-9-19(26)11-20(27)10-18)30-7-5-16(6-8-30)14-34-24-13-23(28)22(12-21(24)17-3-4-17)25(31)29-35(2,32)33/h9-13,15-17H,3-8,14H2,1-2H3,(H,29,31)/t15-/m0/s1

SMILES Code: ClC1=CC(Cl)=CC([C@H](C)N2CCC(COC3=CC(F)=C(C(NS(C)(=O)=O)=O)C=C3C4CC4)CC2)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 543.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Safina BS, McKerrall SJ, Sun S, Chen CA, Chowdhury S, Jia Q, Li J, Zenova AY, Andrez JC, Bankar G, Bergeron P, Chang JH, Chang E, Chen J, Dean R, Decker SM, DiPasquale A, Focken T, Hemeon I, Khakh K, Kim A, Kwan R, Lindgren A, Lin S, Maher J, Mezeyova J, Misner D, Nelkenbrecher K, Pang J, Reese R, Shields SD, Sojo L, Sheng T, Verschoof H, Waldbrook M, Wilson MS, Xie Z, Young C, Zabka TS, Hackos DH, Ortwine DF, White AD, Johnson JP Jr, Robinette CL, Dehnhardt CM, Cohen CJ, Sutherlin DP. Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310. J Med Chem. 2021 Mar 8. doi: 10.1021/acs.jmedchem.1c00049. Epub ahead of print. PMID: 33682420.