GQC-05

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464260

CAS#: 501662-77-7

Description: GQC-05 is a novel high affinity, potent, and selective stabilizer of the MYC G-quadruplex (G4), inducing cytotoxicity with corresponding decreased MYC mRNA and altering protein binding to the NHE III1 region.

Chemical Structure

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GQC-05
CAS# 501662-77-7
Instruction

Theoretical Analysis

MedKoo Cat#: 464260
Name: GQC-05
CAS#: 501662-77-7
Chemical Formula: C21H23N3O
Exact Mass: 333.18
Molecular Weight: 333.435
Elemental Analysis: C, 75.65; H, 6.95; N, 12.60; O, 4.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: GQC-05; GQC05; GQC 05; NSC338258; NSC 338258; NSC-338258;

IUPAC/Chemical Name: 2-((5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-yl)oxy)-N,N-dimethylethan-1-amine

InChi Key: FGFDMBHOYCMKEJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H23N3O/c1-13-18-12-22-8-7-16(18)14(2)21-20(13)17-11-15(5-6-19(17)23-21)25-10-9-24(3)4/h5-8,11-12,23H,9-10H2,1-4H3

SMILES Code: CC1=C(C=NC=C2)C2=C(C)C(N3)=C1C4=C3C=CC(OCCN(C)C)=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 333.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Montoya JJ, Turnidge MA, Wai DH, Patel AR, Lee DW, Gokhale V, Hurley LH, Arceci RJ, Wetmore C, Azorsa DO. In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells. BMC Cancer. 2019 Dec 27;19(1):1251. doi: 10.1186/s12885-019-6464-9. PMID: 31881855; PMCID: PMC6935221.

2: Weldon C, Dacanay JG, Gokhale V, Boddupally PVL, Behm-Ansmant I, Burley GA, Branlant C, Hurley LH, Dominguez C, Eperon IC. Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X. Nucleic Acids Res. 2018 Jan 25;46(2):886-896. doi: 10.1093/nar/gkx1122. PMID: 29156002; PMCID: PMC5778605.

3: Kendrick S, Muranyi A, Gokhale V, Hurley LH, Rimsza LM. Simultaneous Drug Targeting of the Promoter MYC G-Quadruplex and BCL2 i-Motif in Diffuse Large B-Cell Lymphoma Delays Tumor Growth. J Med Chem. 2017 Aug 10;60(15):6587-6597. doi: 10.1021/acs.jmedchem.7b00298. Epub 2017 Jul 25. PMID: 28605593.

4: Brown RV, Danford FL, Gokhale V, Hurley LH, Brooks TA. Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex. J Biol Chem. 2011 Nov 25;286(47):41018-27. doi: 10.1074/jbc.M111.274720. Epub 2011 Sep 28. PMID: 21956115; PMCID: PMC3220475.

5: Tian E, Landowski TH, Stephens OW, Yaccoby S, Barlogie B, Shaughnessy JD Jr. Ellipticine derivative NSC 338258 represents a potential new antineoplastic agent for the treatment of multiple myeloma. Mol Cancer Ther. 2008 Mar;7(3):500-9. doi: 10.1158/1535-7163.MCT-07-0524. Epub 2008 Mar 4. PMID: 18319333.