Guamecycline 2HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576048

CAS#: 13040-98-7

Description: Guamecycline 2HCl is an antibiotic with antitumor activity.

Chemical Structure

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Guamecycline 2HCl
CAS# 13040-98-7
Instruction

Theoretical Analysis

MedKoo Cat#: 576048
Name: Guamecycline 2HCl
CAS#: 13040-98-7
Chemical Formula: C29H40Cl2N8O8
Exact Mass: 698.23
Molecular Weight: 699.590
Elemental Analysis: C, 49.79; H, 5.76; Cl, 10.13; N, 16.02; O, 18.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Guamecycline dihydrochloride; Guamecycline 2HCl; Xanthocycline; Xanthomycin

IUPAC/Chemical Name: 2-Naphthacenecarboxamide, N-((4-(amidinoamidino)-1-piperazinyl)methyl)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, dihydrochloride

InChi Key: SNUNMHCZVZIEMV-KGHBUBBXSA-N

InChi Code: InChI=1S/C29H38N8O8.2ClH/c1-28(44)13-5-4-6-16(38)17(13)21(39)18-14(28)11-15-20(35(2)3)22(40)19(24(42)29(15,45)23(18)41)25(43)33-12-36-7-9-37(10-8-36)27(32)34-26(30)31;;/h4-6,14-15,20,38,40-41,44-45H,7-12H2,1-3H3,(H,33,43)(H5,30,31,32,34);2*1H/t14-,15-,20-,28+,29-;;/m0../s1

SMILES Code: Cl.Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)NCN4CCN(CC4)C(=N)NC(=N)N)C(=O)c5c(O)cccc5[C@@]3(C)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 699.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Logico G, Favero S, Piva A, Conz A. [Bacterial activity and salivary concentration of xanthocycline]. G Stomatol Ortognatodonzia. 1984 Oct-Dec;3(4):718-9. Italian. PubMed PMID: 6443215.

2: Nishimura T, Kitajima J, Omura S, Tanaka N. Antitumor activity of an antibiotic identical with or closely related to xanthomycin A. J Antibiot (Tokyo). 1981 Jul;34(7):856-61. PubMed PMID: 7287588.

3: Bocarnea C, Duminica A. [Guamecycline in the treatment of acute pneumopathies. Clinical research and comparison with other tetracyclines]. Minerva Med. 1972 Nov 21;63(83):4533-6. Italian. PubMed PMID: 4565314.

4: Lányi M, Hordós A, Major T, Tarján E, Zolnay E. Guamecycline in bronchial infections due to Diplococcus pneumoniae. Panminerva Med. 1972 Jan-Feb;14(1-2):24-9. PubMed PMID: 4156979.

5: Bottero A, Pellegrini R, Lops M. [Effects of aerosol administration of guamecycline in patients with broncho-pulmonary diseases]. Epatologia. 1971 Jan-Feb;17(1):85-95. Italian. PubMed PMID: 5147865.